(R)-2-{2-Fluoro-4-[(2-trifluoromethyl-pyridine-4-carbonyl)-amino]-phenyl}-morpholine-4-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(R)-2-{2-Fluoro-4-[(2-trifluoromethyl-pyridine-4-carbonyl)-amino]-phenyl}-morpholine-4-carboxylic acid tert-butyl ester
CAS No.:1415757-60-6
Molecular Formula:C₂₂H₂₃F₄N₃O₄
Molecular Weight:469.436
Hs Code.:

Synonyms:(R)-2-{2-Fluoro-4-[(2-trifluoromethyl-pyridine-4-carbonyl)-amino]-phenyl}-morpholine-4-carboxylic acid tert-butyl ester

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Chemical Property of (R)-2-{2-Fluoro-4-[(2-trifluoromethyl-pyridine-4-carbonyl)-amino]-phenyl}-morpholine-4-carboxylic acid tert-butyl ester

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Technology Process of (R)-2-{2-Fluoro-4-[(2-trifluoromethyl-pyridine-4-carbonyl)-amino]-phenyl}-morpholine-4-carboxylic acid tert-butyl ester

There total 4 articles about (R)-2-{2-Fluoro-4-[(2-trifluoromethyl-pyridine-4-carbonyl)-amino]-phenyl}-morpholine-4-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1400997-83-2
(+)-(R)-2-(4-amino-2-fluorophenyl)morpholine-4-carboxylic acid tert-butyl ester

: 131747-41-6
2-(trifluoromethyl)-4-pyridinecarboxylic acid

: 1415757-60-6
(R)-2-{2-Fluoro-4-[(2-trifluoromethyl-pyridine-4-carbonyl)-amino]-phenyl}-morpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: 2-(trifluoromethyl)-4-pyridinecarboxylic acid; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

(+)-(R)-2-(4-amino-2-fluorophenyl)morpholine-4-carboxylic acid tert-butyl ester; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1415757-61-7
(RS)-2-(4-amino-2-fluorophenyl)morpholine-4-carboxylic acid tert-butyl ester

: 1415757-60-6
(R)-2-{2-Fluoro-4-[(2-trifluoromethyl-pyridine-4-carbonyl)-amino]-phenyl}-morpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Chiralpak AD / isopropyl alcohol; n-heptane / 13501.4 Torr / Resolution of racemate

2.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In n-heptane; dichloromethane; isopropyl alcohol;

Reference yield:

: 1400997-78-5
(RS)-[2-(4-bromo-2-fluorophenyl)-2-hydroxyethyl]-(2-hydroxyethyl)carbamic acid tertbutyl ester

: 1415757-60-6
(R)-2-{2-Fluoro-4-[(2-trifluoromethyl-pyridine-4-carbonyl)-amino]-phenyl}-morpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tert-butyl methyl ether / 20 °C / Inert atmosphere; Cooling with ice

2.1: Chiralpak AD / isopropyl alcohol; n-heptane / 13501.4 Torr / Resolution of racemate

3.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; di-isopropyl azodicarboxylate; triphenylphosphine; In n-heptane; dichloromethane; tert-butyl methyl ether; isopropyl alcohol;