Technology Process of 6,8-dimethoxy-3-(4-hydroxy-3,5-dimethylphenyl)-2H-1,2-benzothiazine-1,1-dioxide
There total 11 articles about 6,8-dimethoxy-3-(4-hydroxy-3,5-dimethylphenyl)-2H-1,2-benzothiazine-1,1-dioxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C26H27NO6S;
With
n-butyllithium;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 14h;
Inert atmosphere;
With
trifluoroacetic acid;
at 80 ℃;
for 96h;
Inert atmosphere;
- Guidance literature:
-
With
trifluoroacetic acid;
at 80 ℃;
for 96h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: carbonic acid dimethyl ester / cyclohexane / 0.25 h / 60 °C / Inert atmosphere
1.2: 1 h / 70 - 72 °C
2.1: 1,3,5-trichloro-2,4,6-triazine; triethylamine / acetone / 20 h / Reflux
2.2: 0.5 h / -78 °C
3.1: 2-(Dimethylamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran / 14 h / -78 - 20 °C / Inert atmosphere
4.2: 96 h / 80 °C / Inert atmosphere
With
2-(Dimethylamino)pyridine; n-butyllithium; 1,3,5-trichloro-2,4,6-triazine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; carbonic acid dimethyl ester;
In
tetrahydrofuran; dichloromethane; cyclohexane; acetone;
