methyl 3-(2-{4-[({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)methyl]phenyl}oxazolo[4,5-b]pyridin-6-yl)propanoate

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Chemical Name:methyl 3-(2-{4-[({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)methyl]phenyl}oxazolo[4,5-b]pyridin-6-yl)propanoate
CAS No.:364385-37-5
Molecular Formula:C₂₈H₃₅N₅O₇
Molecular Weight:553.615
Hs Code.:

Synonyms:methyl 3-(2-{4-[({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)methyl]phenyl}oxazolo[4,5-b]pyridin-6-yl)propanoate

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Chemical Property of methyl 3-(2-{4-[({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)methyl]phenyl}oxazolo[4,5-b]pyridin-6-yl)propanoate

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Technology Process of methyl 3-(2-{4-[({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)methyl]phenyl}oxazolo[4,5-b]pyridin-6-yl)propanoate

There total 7 articles about methyl 3-(2-{4-[({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)methyl]phenyl}oxazolo[4,5-b]pyridin-6-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 322474-21-5
N,N'-bis-Boc-S-methyl-isothiourea

: 364385-34-2
methyl 3-{2-[4-(aminomethyl)phenyl]oxazolo[4,5-b]pyridin-6-yl}propanoate

: 364385-37-5
methyl 3-(2-{4-[({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)methyl]phenyl}oxazolo[4,5-b]pyridin-6-yl)propanoate

Guidance literature:: With triethylamine; mercury dichloride; In N,N-dimethyl-formamide; at 20 ℃; for 4.5h;
DOI:10.3987/com-01-9213

Reference yield:

: 21594-52-5
6-bromo-3H-oxazolo[4,5-b]pyridin-2-one

: 364385-37-5
methyl 3-(2-{4-[({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)methyl]phenyl}oxazolo[4,5-b]pyridin-6-yl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / aq. sodium hydroxide / 8 h / Heating

2: 93 percent / phosphorus pentoxide; hexamethyldisiloxane / 3 h / 200 °C

3: 74 percent / palladium acetate; tri-o-tolylphosphine; triethylamine / dimethylformamide / 24 h / Heating

4: 88 percent / hydrogen / 10 percent Pd/C / dimethylformamide / 48 h / 20 °C / 2280 Torr

5: 100 percent / hydrogen / Raney nickel / dimethylformamide / 48 h / 20 °C / 26600 Torr

6: 91 percent / mercuric chloride; triethylamine / dimethylformamide / 4.5 h / 20 °C

With phosphorus pentaoxide; sodium hydroxide; Hexamethyldisiloxane; hydrogen; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; mercury dichloride; palladium on activated charcoal; nickel; In N,N-dimethyl-formamide;
DOI:10.3987/com-01-9213

Reference yield:

: 60832-72-6
2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-one

: 364385-37-5
methyl 3-(2-{4-[({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)methyl]phenyl}oxazolo[4,5-b]pyridin-6-yl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / Br₂ / dimethylformamide / 2 h / 20 °C

2: 94 percent / aq. sodium hydroxide / 8 h / Heating

3: 93 percent / phosphorus pentoxide; hexamethyldisiloxane / 3 h / 200 °C

4: 74 percent / palladium acetate; tri-o-tolylphosphine; triethylamine / dimethylformamide / 24 h / Heating

5: 88 percent / hydrogen / 10 percent Pd/C / dimethylformamide / 48 h / 20 °C / 2280 Torr

6: 100 percent / hydrogen / Raney nickel / dimethylformamide / 48 h / 20 °C / 26600 Torr

7: 91 percent / mercuric chloride; triethylamine / dimethylformamide / 4.5 h / 20 °C

With phosphorus pentaoxide; sodium hydroxide; Hexamethyldisiloxane; hydrogen; bromine; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; mercury dichloride; palladium on activated charcoal; nickel; In N,N-dimethyl-formamide;
DOI:10.3987/com-01-9213