ethyl 1-methylcycloprop-2-enecarboxylate

Base Information

• Chemical Name: ethyl 1-methylcycloprop-2-enecarboxylate
• CAS No.: 26524-23-2
• Molecular Formula: C₇H₁₀O₂
• Molecular Weight: 126.155
• Mol file: 26524-23-2.mol

Synonyms:ethyl 1-methylcycloprop-2-enecarboxylate

Chemical Property of ethyl 1-methylcycloprop-2-enecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-methylcycloprop-2-enecarboxylate

There total 1 articles about ethyl 1-methylcycloprop-2-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl diazoalaninate (6111-99-5) → ethyl 1-methylcycloprop-2-enecarboxylate (26524-23-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dirhodium(II) tetrakis(triphenylacetate) / dichloromethane / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

With dirhodium(II) tetrakis(triphenylacetate); tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;

DOI:10.1002/anie.201205352 DOI:10.1002/anie.201205352

Reference yield:

ethyl 1-methylcycloprop-2-enecarboxylate (26524-23-2) → C12H14O

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / diethyl ether / -78 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jacs.7b04255

Reference yield:

ethyl 1-methylcycloprop-2-enecarboxylate (26524-23-2) → (S*)-((1S*,2R*,3R*)-2-((benzyloxy)methyl)-2,3-dimethylcyclopropyl)(phenyl)(trimethylsilyl)methanol

Guidance literature:

Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / diethyl ether / -78 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: lithium chloride; copper(I) bromide dimethylsulfide complex / diethyl ether; toluene / 0.33 h / -50 °C / Inert atmosphere

3.2: 0.5 h / -50 - -30 °C / Inert atmosphere

3.3: 2.5 h / -30 - -20 °C / Inert atmosphere; Darkness

With copper(I) bromide dimethylsulfide complex; sodium hydride; diisobutylaluminium hydride; lithium chloride; In tetrahydrofuran; diethyl ether; toluene;

DOI:10.1021/jacs.7b04255

upstream raw materials:

ethyl diazoalaninate