4-[6-(4-hydroxy-phenyl)-3-{(E)-2-[4-(piperidine-1-carbonyl)-phenyl]-vinyl}-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

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Chemical Name:4-[6-(4-hydroxy-phenyl)-3-{(E)-2-[4-(piperidine-1-carbonyl)-phenyl]-vinyl}-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:1426918-46-8
Molecular Formula:C₄₁H₄₈N₆O₆
Molecular Weight:720.869
Hs Code.:

4-[6-(4-hydroxy-phenyl)-3-{(E)-2-[4-(piperidine-1-carbonyl)-phenyl]-vinyl}-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

Synonyms:4-[6-(4-hydroxy-phenyl)-3-{(E)-2-[4-(piperidine-1-carbonyl)-phenyl]-vinyl}-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-[6-(4-hydroxy-phenyl)-3-{(E)-2-[4-(piperidine-1-carbonyl)-phenyl]-vinyl}-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-[6-(4-hydroxy-phenyl)-3-{(E)-2-[4-(piperidine-1-carbonyl)-phenyl]-vinyl}-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

There total 10 articles about 4-[6-(4-hydroxy-phenyl)-3-{(E)-2-[4-(piperidine-1-carbonyl)-phenyl]-vinyl}-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1426918-45-7
4-[6-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(tetrahydro-pyran-2-yl)-3-vinyl-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

: 116772-67-9
(4-iodo-phenyl)-piperidin-1-yl-methanone

: 1426918-46-8
4-[6-(4-hydroxy-phenyl)-3-{(E)-2-[4-(piperidine-1-carbonyl)-phenyl]-vinyl}-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; at 125 ℃; Inert atmosphere;

Reference yield:

: 1711-02-0
4-iodobenzoic acid chloride

: 1426918-46-8
4-[6-(4-hydroxy-phenyl)-3-{(E)-2-[4-(piperidine-1-carbonyl)-phenyl]-vinyl}-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 1.5 h / Reflux

2.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / N,N-dimethyl-formamide / 125 °C / Inert atmosphere

2.2: pH 1 / Acidic conditions

With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In dichloromethane; N,N-dimethyl-formamide; 2.1: |Heck Reaction;

Reference yield:

: 1426918-16-2
6-chloro-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid ethyl ester

: 1426918-46-8
4-[6-(4-hydroxy-phenyl)-3-{(E)-2-[4-(piperidine-1-carbonyl)-phenyl]-vinyl}-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate; iodine / 1,4-dioxane / 72 h / 20 °C

2.1: toluene-4-sulfonic acid / chloroform / 0 - 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 80 °C / Inert atmosphere

4.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water / 1,4-dioxane / Inert atmosphere; Reflux

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; N,N-dimethyl acetamide / 3 h

6.1: 1H-imidazole / dichloromethane / 5 h / 20 °C

7.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / N,N-dimethyl-formamide / 125 °C / Inert atmosphere

7.2: pH 1 / Acidic conditions

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; iodine; palladium diacetate; sodium hydrogencarbonate; benzotriazol-1-ol; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tris-(o-tolyl)phosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl acetamide; N,N-dimethyl-formamide; 4.1: |Suzuki Coupling / 7.1: |Heck Reaction;