4-(2''',6'''-Bis-bromomethyl-2''-methoxymethoxymethyl-[1,1';2',1'';4'',1''']quaterphenyl-3-yl)-1-trityl-1H-imidazole

Base Information

Chemical Name:4-(2''',6'''-Bis-bromomethyl-2''-methoxymethoxymethyl-[1,1';2',1'';4'',1''']quaterphenyl-3-yl)-1-trityl-1H-imidazole
CAS No.:108780-65-0
Molecular Formula:C₅₁H₄₂Br₂N₂O₂
Molecular Weight:874.715
Hs Code.:

Synonyms:4-(2''',6'''-Bis-bromomethyl-2''-methoxymethoxymethyl-[1,1';2',1'';4'',1''']quaterphenyl-3-yl)-1-trityl-1H-imidazole

Suppliers and Price of 4-(2''',6'''-Bis-bromomethyl-2''-methoxymethoxymethyl-[1,1';2',1'';4'',1''']quaterphenyl-3-yl)-1-trityl-1H-imidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(2''',6'''-Bis-bromomethyl-2''-methoxymethoxymethyl-[1,1';2',1'';4'',1''']quaterphenyl-3-yl)-1-trityl-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(2''',6'''-Bis-bromomethyl-2''-methoxymethoxymethyl-[1,1';2',1'';4'',1''']quaterphenyl-3-yl)-1-trityl-1H-imidazole

There total 15 articles about 4-(2''',6'''-Bis-bromomethyl-2''-methoxymethoxymethyl-[1,1';2',1'';4'',1''']quaterphenyl-3-yl)-1-trityl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 108780-69-4
1-trityl-4-(2''',6'''-bis-2''-methoxymethoxymethyl<1,1':2',1'':4'':1'''-quaterphenyl>-3-yl)imidazole

: 108780-65-0
4-(2''',6'''-Bis-bromomethyl-2''-methoxymethoxymethyl-[1,1';2',1'';4'',1''']quaterphenyl-3-yl)-1-trityl-1H-imidazole

Guidance literature:: With N-Bromosuccinimide; triphenylphosphine; In tetrahydrofuran; at 25 ℃; for 3h;
DOI:10.1016/S0040-4020(01)87577-3

Reference yield:

: 615-59-8
1,4-dibromo-2-methylbenzene

: 108780-65-0
4-(2''',6'''-Bis-bromomethyl-2''-methoxymethoxymethyl-[1,1';2',1'';4'',1''']quaterphenyl-3-yl)-1-trityl-1H-imidazole

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) Mg, 2.) Br₂ / 1.) THF, heating, 3 h, 2.)pentane, -78 deg C, 2 h

2: 27.4 g / NBS / CCl₄ / 0.33 h / Heating; Irradiation

3: aq NaHCO₃ / acetonitrile / 5 h / Heating

4: 1.) CH₃I, 2.) aq NaOH / 1.) CH₃NO₂,acetone, MeOH, 2.) reflux, 24 h

5: 6.2 g / 50percent NaH, / tetrahydrofuran / 14 h / 25 °C

6: LiAlH₄ / diethyl ether / 2 h / Heating

7: 64 percent / imidazole / dimethylformamide / 24 h / 25 °C

8: 1.) t-BuLI, ZnCl₂, 2.) Pd_.PPh₃ / 1.) THF, -78 deg C, 2.) 25 deg C, 14 h

9: 87 percent / Bu₄NF / tetrahydrofuran / 0.5 h

10: 82 percent / Ph₃P, n-bromosuccinimide / tetrahydrofuran / 3 h / 25 °C

With 1H-imidazole; sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; palladium-triphenylphosphine; tetrabutyl ammonium fluoride; bromine; tert.-butyl lithium; sodium hydride; sodium hydrogencarbonate; magnesium; triphenylphosphine; zinc(II) chloride; methyl iodide; In tetrahydrofuran; tetrachloromethane; diethyl ether; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4020(01)87577-3

Reference yield:

: 76-83-5
trityl chloride

: 108780-65-0
4-(2''',6'''-Bis-bromomethyl-2''-methoxymethoxymethyl-[1,1';2',1'';4'',1''']quaterphenyl-3-yl)-1-trityl-1H-imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether; triethylamine / 25 °C

2: 1.) t-BuLI, ZnCl₂, 2.) Pd_.PPh₃ / 1.) THF, -78 deg C, 2.) 25 deg C, 14 h

3: 87 percent / Bu₄NF / tetrahydrofuran / 0.5 h

4: 82 percent / Ph₃P, n-bromosuccinimide / tetrahydrofuran / 3 h / 25 °C

With N-Bromosuccinimide; palladium-triphenylphosphine; tetrabutyl ammonium fluoride; tert.-butyl lithium; triphenylphosphine; zinc(II) chloride; In tetrahydrofuran; diethyl ether; triethylamine;
DOI:10.1016/S0040-4020(01)87577-3