2-allyl 3,4-dimethyl 5-((R)-3-(3-((R)-1-oxo-3-phenyl-1-(prop-2-ynylamino)propan-2-yl)ureido)-4-(triisopropylsilyloxy)butyl)furan-2,3,4-tricarboxylate

Base Information

Chemical Name:2-allyl 3,4-dimethyl 5-((R)-3-(3-((R)-1-oxo-3-phenyl-1-(prop-2-ynylamino)propan-2-yl)ureido)-4-(triisopropylsilyloxy)butyl)furan-2,3,4-tricarboxylate
CAS No.:890139-62-5
Molecular Formula:C₃₈H₅₃N₃O₁₀Si
Molecular Weight:739.938
Hs Code.:

Synonyms:2-allyl 3,4-dimethyl 5-((R)-3-(3-((R)-1-oxo-3-phenyl-1-(prop-2-ynylamino)propan-2-yl)ureido)-4-(triisopropylsilyloxy)butyl)furan-2,3,4-tricarboxylate

Suppliers and Price of 2-allyl 3,4-dimethyl 5-((R)-3-(3-((R)-1-oxo-3-phenyl-1-(prop-2-ynylamino)propan-2-yl)ureido)-4-(triisopropylsilyloxy)butyl)furan-2,3,4-tricarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-allyl 3,4-dimethyl 5-((R)-3-(3-((R)-1-oxo-3-phenyl-1-(prop-2-ynylamino)propan-2-yl)ureido)-4-(triisopropylsilyloxy)butyl)furan-2,3,4-tricarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-allyl 3,4-dimethyl 5-((R)-3-(3-((R)-1-oxo-3-phenyl-1-(prop-2-ynylamino)propan-2-yl)ureido)-4-(triisopropylsilyloxy)butyl)furan-2,3,4-tricarboxylate

There total 4 articles about 2-allyl 3,4-dimethyl 5-((R)-3-(3-((R)-1-oxo-3-phenyl-1-(prop-2-ynylamino)propan-2-yl)ureido)-4-(triisopropylsilyloxy)butyl)furan-2,3,4-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-5-Triisopropylsilanyloxymethyl-pyrrolidin-2-one

: 890139-62-5
2-allyl 3,4-dimethyl 5-((R)-3-(3-((R)-1-oxo-3-phenyl-1-(prop-2-ynylamino)propan-2-yl)ureido)-4-(triisopropylsilyloxy)butyl)furan-2,3,4-tricarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N; TMSCl / CH₂Cl₂ / 1.5 h / 20 °C

2: DMAP; diisopropylcarbodiimide / CH₂Cl₂ / 12 h

3: MsN₃; Et₃N / acetonitrile

4: Rh₂Oct₄ / benzene / 1.5 h / 95 °C

5: 612 mg / benzene / 12 h / 20 °C

With dmap; chloro-trimethyl-silane; triethylamine; Methanesulfonyl azide; diisopropyl-carbodiimide; rhodium (II) octanoate dimer; In dichloromethane; acetonitrile; benzene;
DOI:10.1021/ol0604724

Reference yield:

: 3-Oxo-3-((R)-2-oxo-5-triisopropylsilanyloxymethyl-pyrrolidin-1-yl)-propionic acid

: 890139-62-5
2-allyl 3,4-dimethyl 5-((R)-3-(3-((R)-1-oxo-3-phenyl-1-(prop-2-ynylamino)propan-2-yl)ureido)-4-(triisopropylsilyloxy)butyl)furan-2,3,4-tricarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: DMAP; diisopropylcarbodiimide / CH₂Cl₂ / 12 h

2: MsN₃; Et₃N / acetonitrile

3: Rh₂Oct₄ / benzene / 1.5 h / 95 °C

4: 612 mg / benzene / 12 h / 20 °C

With dmap; triethylamine; Methanesulfonyl azide; diisopropyl-carbodiimide; rhodium (II) octanoate dimer; In dichloromethane; acetonitrile; benzene;
DOI:10.1021/ol0604724

Reference yield:

: 890139-63-6
2-Diazo-3-oxo-3-((R)-2-oxo-5-triisopropylsilanyloxymethyl-pyrrolidin-1-yl)-propionic acid allyl ester

: 890139-62-5
2-allyl 3,4-dimethyl 5-((R)-3-(3-((R)-1-oxo-3-phenyl-1-(prop-2-ynylamino)propan-2-yl)ureido)-4-(triisopropylsilyloxy)butyl)furan-2,3,4-tricarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Rh₂Oct₄ / benzene / 1.5 h / 95 °C

2: 612 mg / benzene / 12 h / 20 °C

rhodium (II) octanoate dimer; In benzene;
DOI:10.1021/ol0604724