(S)-2-[[[1-(2-amino ethyl)cyclopentyl]carbonyl]amino]-3-[4-(2,6-dichlorobenzoylamino)phenyl]propionic acid methyl ester

Base Information

Chemical Name:(S)-2-[[[1-(2-amino ethyl)cyclopentyl]carbonyl]amino]-3-[4-(2,6-dichlorobenzoylamino)phenyl]propionic acid methyl ester
CAS No.:220877-86-1
Molecular Formula:C₂₅H₂₉Cl₂N₃O₄
Molecular Weight:506.429
Hs Code.:

Synonyms:(S)-2-[[[1-(2-amino ethyl)cyclopentyl]carbonyl]amino]-3-[4-(2,6-dichlorobenzoylamino)phenyl]propionic acid methyl ester

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Chemical Property of (S)-2-[[[1-(2-amino ethyl)cyclopentyl]carbonyl]amino]-3-[4-(2,6-dichlorobenzoylamino)phenyl]propionic acid methyl ester

Chemical Property:

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Technology Process of (S)-2-[[[1-(2-amino ethyl)cyclopentyl]carbonyl]amino]-3-[4-(2,6-dichlorobenzoylamino)phenyl]propionic acid methyl ester

There total 11 articles about (S)-2-[[[1-(2-amino ethyl)cyclopentyl]carbonyl]amino]-3-[4-(2,6-dichlorobenzoylamino)phenyl]propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 220880-36-4
(S)-2-[[1-(2-azido-ethyl)-cyclopentanecarbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid methyl ester

: 220877-86-1
(S)-2-[[[1-(2-amino ethyl)cyclopentyl]carbonyl]amino]-3-[4-(2,6-dichlorobenzoylamino)phenyl]propionic acid methyl ester

Guidance literature:: (S)-2-[[1-(2-azido-ethyl)-cyclopentanecarbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid methyl ester; With trimethylphosphane; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

With water; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 220880-36-4
(S)-2-[[1-(2-azido-ethyl)-cyclopentanecarbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid methyl ester

: 594-09-2
trimethylphosphane

: methyl 4-[[(2,6-dichlorophenyl)carbonyl]amino]-N-[[1-(2-aminoethyl)cyclopentyl]carbonyl]-L-phenylalanine ester

: 220877-86-1
(S)-2-[[[1-(2-amino ethyl)cyclopentyl]carbonyl]amino]-3-[4-(2,6-dichlorobenzoylamino)phenyl]propionic acid methyl ester

Guidance literature:: In tetrahydrofuran; dichloromethane; water; toluene;

Reference yield:

: 4630-80-2
methyl cyclopentane carboxylate

: 220877-86-1
(S)-2-[[[1-(2-amino ethyl)cyclopentyl]carbonyl]amino]-3-[4-(2,6-dichlorobenzoylamino)phenyl]propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: LDA / tetrahydrofuran / 15 h / -70 - 20 °C

2: NaN₃ / dimethylformamide / 15 h / 50 °C

3: 1.0 N NaOH / methanol; tetrahydrofuran / 15 h / Heating

4: HBTU; DIPEA / dimethylformamide / 20 °C

5: Me₃P; H₂O / toluene

With sodium hydroxide; sodium azide; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; trimethylphosphane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0960-894X(02)00386-4