tert-butyl (R)-1-(2'-chlorobiphenyl-4-yl)-4-((R)-3-(1-(3-methoxypropyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl (R)-1-(2'-chlorobiphenyl-4-yl)-4-((R)-3-(1-(3-methoxypropyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutan-2-yl)carbamate
CAS No.:1365885-82-0
Molecular Formula:C₃₇H₄₅ClN₄O₄
Molecular Weight:645.242
Hs Code.:

Synonyms:tert-butyl (R)-1-(2'-chlorobiphenyl-4-yl)-4-((R)-3-(1-(3-methoxypropyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutan-2-yl)carbamate

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Chemical Property of tert-butyl (R)-1-(2'-chlorobiphenyl-4-yl)-4-((R)-3-(1-(3-methoxypropyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutan-2-yl)carbamate

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Technology Process of tert-butyl (R)-1-(2'-chlorobiphenyl-4-yl)-4-((R)-3-(1-(3-methoxypropyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutan-2-yl)carbamate

There total 8 articles about tert-butyl (R)-1-(2'-chlorobiphenyl-4-yl)-4-((R)-3-(1-(3-methoxypropyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365884-39-4
tert-butyl (R)-1-(4-bromophenyl)-4-((R)-3-(1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutan-2-ylcarbamate

: 3900-89-8
2-Chlorobenzeneboronic acid

: 1365885-82-0
tert-butyl (R)-1-(2'-chlorobiphenyl-4-yl)-4-((R)-3-(1-(3-methoxypropyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutan-2-yl)carbamate

Guidance literature:: With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 110 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 163438-09-3
(R)-1-Boc-nipecotic acid

: 1365885-82-0
tert-butyl (R)-1-(2'-chlorobiphenyl-4-yl)-4-((R)-3-(1-(3-methoxypropyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2.1: acetic acid / 2 h / 65 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C

4.1: hydrogenchloride; water / ethanol / 0.17 h / Inert atmosphere; Reflux

5.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 20 °C

6.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.17 h / 110 °C / Microwave irradiation

With 4-methyl-morpholine; hydrogenchloride; water; sodium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 95-54-5
1,2-diamino-benzene

: 1365885-82-0
tert-butyl (R)-1-(2'-chlorobiphenyl-4-yl)-4-((R)-3-(1-(3-methoxypropyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2.1: acetic acid / 2 h / 65 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C

4.1: hydrogenchloride; water / ethanol / 0.17 h / Inert atmosphere; Reflux

5.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 20 °C

6.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.17 h / 110 °C / Microwave irradiation

With 4-methyl-morpholine; hydrogenchloride; water; sodium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; mineral oil;