4,4-dimethyl-3-phenylpentanoyl chloride

Base Information

• Chemical Name: 4,4-dimethyl-3-phenylpentanoyl chloride
• CAS No.: 103085-18-3
• Molecular Formula: C₁₃H₁₇ClO
• Molecular Weight: 224.73
• Mol file: 103085-18-3.mol

Synonyms:4,4-dimethyl-3-phenylpentanoyl chloride

Chemical Property of 4,4-dimethyl-3-phenylpentanoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4-dimethyl-3-phenylpentanoyl chloride

There total 3 articles about 4,4-dimethyl-3-phenylpentanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(+/-)-4,4-dimethyl-3-phenylpentanoic acid (83867-96-3) → 4,4-dimethyl-3-phenylpentanoyl chloride (103085-18-3)

Guidance literature:

With thionyl chloride; for 2.5h; Heating;

Reference yield:

(E)-3-phenylacrylic acid (140-10-3) → 4,4-dimethyl-3-phenylpentanoyl chloride (103085-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / diethyl ether / 4 h / 0 °C

2: 91 percent / SOCl₂ / 2.5 h / Heating

With thionyl chloride; In diethyl ether;

Reference yield:

Cinnamic acid (621-82-9) → 4,4-dimethyl-3-phenylpentanoyl chloride (103085-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diethyl ether / 3 h / 0 °C / Inert atmosphere; Reflux

1.2: Cooling with ice

2.1: thionyl chloride / 3 h / Reflux; Inert atmosphere

With thionyl chloride; In diethyl ether;

DOI:10.1016/j.tetasy.2010.12.019

upstream raw materials:

(+/-)-4,4-dimethyl-3-phenylpentanoic acid

(E)-3-phenylacrylic acid

Cinnamic acid

Downstream raw materials:

2-Diazo-5-phenyl-6,6-dimethylheptan-3-one

(+/-)-ethyl 4,4-dimethyl-3-phenylpentanoate

(R)-ethyl 4,4-dimethyl-3-phenylpentanoate

(S)-ethyl 4,4-dimethyl-3-phenylpentanoate