3-{3-[(2R,3S)-1-(4-methoxybenzyl)-3-(methoxymethoxy)-6-oxopiperidin-2-yl]-2-oxopropyl}-3,4-dihydroquinazolin-4-one

Base Information

Chemical Name:3-{3-[(2R,3S)-1-(4-methoxybenzyl)-3-(methoxymethoxy)-6-oxopiperidin-2-yl]-2-oxopropyl}-3,4-dihydroquinazolin-4-one
CAS No.:616890-53-0
Molecular Formula:C₂₆H₂₉N₃O₆
Molecular Weight:479.533
Hs Code.:

Synonyms:3-{3-[(2R,3S)-1-(4-methoxybenzyl)-3-(methoxymethoxy)-6-oxopiperidin-2-yl]-2-oxopropyl}-3,4-dihydroquinazolin-4-one

Suppliers and Price of 3-{3-[(2R,3S)-1-(4-methoxybenzyl)-3-(methoxymethoxy)-6-oxopiperidin-2-yl]-2-oxopropyl}-3,4-dihydroquinazolin-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-{3-[(2R,3S)-1-(4-methoxybenzyl)-3-(methoxymethoxy)-6-oxopiperidin-2-yl]-2-oxopropyl}-3,4-dihydroquinazolin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-{3-[(2R,3S)-1-(4-methoxybenzyl)-3-(methoxymethoxy)-6-oxopiperidin-2-yl]-2-oxopropyl}-3,4-dihydroquinazolin-4-one

There total 12 articles about 3-{3-[(2R,3S)-1-(4-methoxybenzyl)-3-(methoxymethoxy)-6-oxopiperidin-2-yl]-2-oxopropyl}-3,4-dihydroquinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-{2-Hydroxy-3-[(2R,3S)-1-(4-methoxy-benzyl)-3-methoxymethoxy-6-oxo-piperidin-2-yl]-propyl}-3H-quinazolin-4-one

: 616890-53-0
3-{3-[(2R,3S)-1-(4-methoxybenzyl)-3-(methoxymethoxy)-6-oxopiperidin-2-yl]-2-oxopropyl}-3,4-dihydroquinazolin-4-one

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/jm0302086

Reference yield:

: 616890-45-0
(3S,4R)-4-(dibenzylamino)-6-(tert-butyldimethylsilyloxy)hex-1-en-3-ol

: 616890-53-0
3-{3-[(2R,3S)-1-(4-methoxybenzyl)-3-(methoxymethoxy)-6-oxopiperidin-2-yl]-2-oxopropyl}-3,4-dihydroquinazolin-4-one

Guidance literature:: Multi-step reaction with 12 steps

1.1: 83 percent / ethyldiisopropylamine; KI / 1,2-dimethoxy-ethane / 3 h / Heating

2.1: 81 percent / trimethylamine oxide dihydrate; OsO₄ / tetrahydrofuran; 2-methyl-propan-2-ol; H₂O / 5 h / 20 °C

3.1: aq. NaIO₄ / diethyl ether / 3 h / 0 °C

4.1: NaH / toluene

4.2: 1.96 g / toluene / 2 h / 0 °C

5.1: H₂ / Pd(OH)2/C / ethanol / 5 h / 20 °C / 760 Torr

6.1: 448 mg / EDCI*HCl / tetrahydrofuran / 4 h

7.1: 50 percent / NaH / dimethylformamide / 5.5 h / 20 °C

8.1: 86 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

9.1: Dess-Martin periodinane / CH₂Cl₂ / 1 h / 0 °C

10.1: 18.6 mg / NaH / dimethylsulfoxide / 2 h / 20 °C

11.1: KH / dimethylformamide / 0.5 h / 0 °C

11.2: dimethylformamide / 3.5 h / 80 °C

12.1: 19.8 mg / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 °C

With sodium periodate; osmium(VIII) oxide; trimethylamine-N-oxide; tetrabutyl ammonium fluoride; hydrogen; potassium hydride; sodium hydride; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium iodide; palladium dihydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 4.2: Horner-Emmons reaction / 9.1: Dess-Martin oxidation / 12.1: Dess-Martin oxidation;
DOI:10.1021/jm0302086

Reference yield:

: (2R,3R)-3-(dibenzylamino)-5-(tert-butyldimethylsilyloxy)-2-(methoxymethoxy)pentanal

: 616890-53-0
3-{3-[(2R,3S)-1-(4-methoxybenzyl)-3-(methoxymethoxy)-6-oxopiperidin-2-yl]-2-oxopropyl}-3,4-dihydroquinazolin-4-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: NaH / toluene

1.2: 1.96 g / toluene / 2 h / 0 °C

2.1: H₂ / Pd(OH)2/C / ethanol / 5 h / 20 °C / 760 Torr

3.1: 448 mg / EDCI*HCl / tetrahydrofuran / 4 h

4.1: 50 percent / NaH / dimethylformamide / 5.5 h / 20 °C

5.1: 86 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

6.1: Dess-Martin periodinane / CH₂Cl₂ / 1 h / 0 °C

7.1: 18.6 mg / NaH / dimethylsulfoxide / 2 h / 20 °C

8.1: KH / dimethylformamide / 0.5 h / 0 °C

8.2: dimethylformamide / 3.5 h / 80 °C

9.1: 19.8 mg / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 °C

With tetrabutyl ammonium fluoride; hydrogen; potassium hydride; sodium hydride; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 1.2: Horner-Emmons reaction / 6.1: Dess-Martin oxidation / 9.1: Dess-Martin oxidation;
DOI:10.1021/jm0302086