3-{3-isopropoxy-1-[2-methyl-4-(trifluoromethyl)benzyl]-1H-pyrazole-5-yl}propane-1-ol

Base Information

• Chemical Name: 3-{3-isopropoxy-1-[2-methyl-4-(trifluoromethyl)benzyl]-1H-pyrazole-5-yl}propane-1-ol
• CAS No.: 888739-71-7
• Molecular Formula: C₁₈H₂₃F₃N₂O₂
• Molecular Weight: 356.388

Synonyms:3-{3-isopropoxy-1-[2-methyl-4-(trifluoromethyl)benzyl]-1H-pyrazole-5-yl}propane-1-ol

Chemical Property of 3-{3-isopropoxy-1-[2-methyl-4-(trifluoromethyl)benzyl]-1H-pyrazole-5-yl}propane-1-ol

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Technology Process of 3-{3-isopropoxy-1-[2-methyl-4-(trifluoromethyl)benzyl]-1H-pyrazole-5-yl}propane-1-ol

There total 1 articles about 3-{3-isopropoxy-1-[2-methyl-4-(trifluoromethyl)benzyl]-1H-pyrazole-5-yl}propane-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-{3-isopropoxy-1-[2-methyl-4-(trifluoromethyl)benzyl]-1H-pyrazole-5-yl}propionic acid ethyl ester (888739-70-6) → 3-{3-isopropoxy-1-[2-methyl-4-(trifluoromethyl)benzyl]-1H-pyrazole-5-yl}propane-1-ol (888739-71-7)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; methanol; toluene;

Reference yield: 98.0%

[1-benzyl-3-hydroxy-1H-pyrazole-4-yl]acetic acid methyl ester (888739-84-2) + 3-{3-isopropoxy-1-[2-methyl-4-(trifluoromethyl)benzyl]-1H-pyrazole-5-yl}propane-1-ol (888739-71-7) + 1,1'-(Azodicarbonyl)dipiperidin (10465-81-3,871024-86-1) → [1-benzyl-3-(3-{3-isopropoxy-1-[2-methyl-4-(trifluoromethyl)benzyl]-1H-pyrazol-5-yl}propoxy)-1H-pyrazol-4-yl]acetic acid (888742-38-9)

Guidance literature:

With hydrogenchloride; sodium hydroxide; tributylphosphine; In tetrahydrofuran; ethanol; di-isopropyl ether;

Reference yield: 71.0%

3-{3-isopropoxy-1-[2-methyl-4-(trifluoromethyl)benzyl]-1H-pyrazole-5-yl}propane-1-ol (888739-71-7) + methyl (2-hydroxypyridin-3-yl)acetate (441357-30-8) + 1,1'-(Azodicarbonyl)dipiperidin (10465-81-3,871024-86-1) → [2-(3-{3-isopropoxy-1-[2-methyl-4-(trifluoromethyl)benzyl]-1H-pyrazol-5-yl}propoxy)pyridin-3-yl]acetic acid (888742-40-3)

Guidance literature:

With hydrogenchloride; sodium hydroxide; tributylphosphine; In tetrahydrofuran; methanol; di-isopropyl ether;

upstream raw materials:

3-{3-isopropoxy-1-[2-methyl-4-(trifluoromethyl)benzyl]-1H-pyrazole-5-yl}propionic acid ethyl ester

Downstream raw materials:

[1-benzyl-3-(3-{3-isopropoxy-1-[2-methyl-4-(trifluoromethyl)benzyl]-1H-pyrazol-5-yl}propoxy)-1H-pyrazol-4-yl]acetic acid

[2-(3-{3-isopropoxy-1-[2-methyl-4-(trifluoromethyl)benzyl]-1H-pyrazol-5-yl}propoxy)pyridin-3-yl]acetic acid

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