5-iodo-1,2,3-trihydroxybenzene

Base Information

• Chemical Name: 5-iodo-1,2,3-trihydroxybenzene
• CAS No.: 1014621-87-4
• Molecular Formula: C₆H₅IO₃
• Molecular Weight: 252.008
• Mol file: 1014621-87-4.mol

Synonyms:5-iodo-1,2,3-trihydroxybenzene

Chemical Property of 5-iodo-1,2,3-trihydroxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-iodo-1,2,3-trihydroxybenzene

There total 2 articles about 5-iodo-1,2,3-trihydroxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

5-iodo-1,2,3-trimethoxybenzene (25245-29-8) → 5-iodo-1,2,3-trihydroxybenzene (1014621-87-4)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/ja0765316

Reference yield:

3,4,5-Trimethoxyaniline (24313-88-0) → 5-iodo-1,2,3-trihydroxybenzene (1014621-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / acetonitrile; water / 0.33 h / 0 °C

1.2: 1 h / 0 - 5 °C

1.3: 0 - 20 °C

2.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

With hydrogenchloride; boron tribromide; In dichloromethane; water; acetonitrile;

DOI:10.1039/c5cc00476d

Reference yield: 90.0%

5-iodo-1,2,3-trihydroxybenzene (1014621-87-4) + 1-dodecylbromide (143-15-7) → 3,4,5-tris(n-dodecan-1-yloxy)-1-iodobenzene (851608-71-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 7h;

DOI:10.1021/ja0765316

upstream raw materials:

5-iodo-1,2,3-trimethoxybenzene

3,4,5-Trimethoxyaniline

Downstream raw materials:

3,4,5-tris(n-dodecan-1-yloxy)-1-iodobenzene

(3,4,5-tris(dodecyloxy)phenyl)boronic acid