2,6-Difluoro-3-methylaniline

Base Information

• Chemical Name: 2,6-Difluoro-3-methylaniline
• CAS No.: 144851-63-8
• Molecular Formula: C₇H₇F₂N
• Molecular Weight: 143.136
• Hs Code.: 2921420090
• European Community (EC) Number: 678-650-5
• DSSTox Substance ID: DTXSID40566998
• Wikidata: Q82452776
• Mol file: 144851-63-8.mol

Synonyms:2,6-Difluoro-3-methylaniline;144851-63-8;MFCD06660182;2,6-Difluoro-3-methyl-aniline;Benzenamine, 2,6-difluoro-3-methyl-;SCHEMBL3725651;DTXSID40566998;ZMNJSSZHDRBGNN-UHFFFAOYSA-N;AKOS006342680;JS-4368;SB75450;SY228018;EN300-115864;F81219;A935596;Z1203583074

Chemical Property of 2,6-Difluoro-3-methylaniline

Chemical Property:

• Boiling Point: 170.9±35.0 °C(Predicted)
• PKA: 1.94±0.10(Predicted)
• Density: 1.229±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: Soluble in organic solvents.
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 143.05465555
• Heavy Atom Count: 10
• Complexity: 118

Purity/Quality:

95%mini, ^*data from raw suppliers

2,6-Difluoro-3-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C(=C(C=C1)F)N)F
• Uses: 2,6-Difluoro-3-methylaniline is used as a solvent is convenient as the pyridine can serve both as the solvent and the catalyst in the transformation.

Technology Process of 2,6-Difluoro-3-methylaniline

There total 1 articles about 2,6-Difluoro-3-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2,6-difluoro-3-methylaniline (144851-63-8)

Guidance literature:

Reference yield: 99.0%

2,6-difluoro-3-methylaniline (144851-63-8) + acetic anhydride (108-24-7) → N-(2,6-difluoro-3-methylphenyl)acetamide

Guidance literature:

at 60 ℃; for 2h;

Reference yield: 81.0%

2,6-difluoro-3-methylaniline (144851-63-8) → 4-bromo-2,6-difluoro-3-methylaniline (1035690-38-0)

Guidance literature:

With bromine; acetic acid; at 55 ℃; for 1h;

Downstream raw materials:

4-bromo-2,6-difluoro-3-methylaniline

Refernces