ethyl allyl((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenylpropyl)phosphinate

Base Information

Chemical Name:ethyl allyl((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenylpropyl)phosphinate
CAS No.:492455-72-8
Molecular Formula:C₂₈H₃₄NO₃P
Molecular Weight:463.557
Hs Code.:

Synonyms:ethyl allyl((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenylpropyl)phosphinate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl allyl((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenylpropyl)phosphinate

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Technology Process of ethyl allyl((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenylpropyl)phosphinate

There total 1 articles about ethyl allyl((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenylpropyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 123054-12-6,123808-74-2,136370-73-5,111060-64-1
(2S)-N,N-dibenzylphenylalaninal

: 173781-45-8
ethyl allyl-H-phosphinate

: 492455-79-5
ethyl allyl((1R,2S)-2-dibenzylamino-1-hydroxy-3-phenylpropyl)phosphinate

: 492455-72-8
ethyl allyl((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenylpropyl)phosphinate

Guidance literature:: With n-butyllithium; phenol; In tetrahydrofuran; hexane; at -40 ℃; for 12h;
DOI:10.1016/S0040-4020(02)01629-0

Reference yield:

: 492455-72-8
ethyl allyl((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenylpropyl)phosphinate

: ((1S,2S)-2-Amino-1-hydroxy-3-phenyl-propyl)-propyl-phosphinic acid ethyl ester

Guidance literature:: With hydrogen; palladium dihydroxide; In ethanol;
DOI:10.1055/s-2002-33529

Reference yield:

: 492455-72-8
ethyl allyl((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenylpropyl)phosphinate

: ((4S,5S)-4-Benzyl-2-oxo-oxazolidin-5-yl)-propyl-phosphinic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂ / 20 percent Pd(OH)2/C / ethanol

2.1: NMO / tetrahydrofuran

3.1: TMSBr / CH₂Cl₂

3.2: MeOH

With N-methyl-2-indolinone; trimethylsilyl bromide; hydrogen; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1055/s-2002-33529