(R)-2-[2-({(R)-4-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester

Base Information

Chemical Name:(R)-2-[2-({(R)-4-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester
CAS No.:196938-93-9
Molecular Formula:C₃₁H₄₅N₅O₁₂
Molecular Weight:679.725
Hs Code.:

(R)-2-[2-({(R)-4-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester

Synonyms:(R)-2-[2-({(R)-4-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester

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Chemical Property of (R)-2-[2-({(R)-4-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester

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Technology Process of (R)-2-[2-({(R)-4-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester

There total 17 articles about (R)-2-[2-({(R)-4-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 182748-71-6
(R)-2-[2-({(R)-4-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 4-benzyl ester 1-methyl ester

: 196938-93-9
(R)-2-[2-({(R)-4-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethanol; for 5h; Ambient temperature;

Reference yield:

: 35793-73-8
N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid

: 196938-93-9
(R)-2-[2-({(R)-4-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 100 percent / diethyl ether / 0.5 h / 0 °C

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 3 h / Ambient temperature

3: 4-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

4: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 0.75 h / Ambient temperature

5: 98 percent / H₂ / 10percent Pd/C / ethanol / 3 h / Ambient temperature

6: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 0.83 h / Ambient temperature

7: 89 percent / HCl / ethyl acetate / 2 h / Ambient temperature

8: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 3 h / Ambient temperature

9: 98 percent / H₂ / 10percent Pd/C / ethanol; methanol / 5 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 55227-00-4
α-Methyl (2R)-N-(tert-butoxycarbonyl)glutamate ester

: 196938-93-9
(R)-2-[2-({(R)-4-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 4-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

2: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 0.75 h / Ambient temperature

3: 98 percent / H₂ / 10percent Pd/C / ethanol / 3 h / Ambient temperature

4: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 0.83 h / Ambient temperature

5: 89 percent / HCl / ethyl acetate / 2 h / Ambient temperature

6: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 3 h / Ambient temperature

7: 98 percent / H₂ / 10percent Pd/C / ethanol; methanol / 5 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;