(5S,8R,10S,14S,15R,18S,19R,22S,24aS)-18-Amino-14-hydroxy-5-isobutyl-10,15-diisopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone

Base Information

Chemical Name:(5S,8R,10S,14S,15R,18S,19R,22S,24aS)-18-Amino-14-hydroxy-5-isobutyl-10,15-diisopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone
CAS No.:117733-99-0
Molecular Formula:C₄₁H₆₃N₅O₁₁
Molecular Weight:801.978
Hs Code.:

(5S,8R,10S,14S,15R,18S,19R,22S,24aS)-18-Amino-14-hydroxy-5-isobutyl-10,15-diisopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone

Synonyms:(5S,8R,10S,14S,15R,18S,19R,22S,24aS)-18-Amino-14-hydroxy-5-isobutyl-10,15-diisopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone

Suppliers and Price of (5S,8R,10S,14S,15R,18S,19R,22S,24aS)-18-Amino-14-hydroxy-5-isobutyl-10,15-diisopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5S,8R,10S,14S,15R,18S,19R,22S,24aS)-18-Amino-14-hydroxy-5-isobutyl-10,15-diisopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5S,8R,10S,14S,15R,18S,19R,22S,24aS)-18-Amino-14-hydroxy-5-isobutyl-10,15-diisopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone

There total 14 articles about (5S,8R,10S,14S,15R,18S,19R,22S,24aS)-18-Amino-14-hydroxy-5-isobutyl-10,15-diisopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 117710-17-5
cyclo-oxy-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-(N,O-dimethyl-L-tyrosyl)>-L-threonyl>

: 117733-99-0
(5S,10S,14S,15R,18S,22S,24aS)-18-Amino-14-hydroxy-5-isobutyl-10,15-diisopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 2h; under 760 Torr; Ambient temperature;
DOI:10.1021/jo00264a022

Reference yield:

: 22838-58-0
Boc-D-Val-OH

: 117733-99-0
(5S,10S,14S,15R,18S,22S,24aS)-18-Amino-14-hydroxy-5-isobutyl-10,15-diisopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone

Guidance literature:: Multi-step reaction with 14 steps

1: 98 percent / triethylamine (TEA) / tetrahydrofuran / 2 h / 0 - 5 °C

2: lithium diisopropylamide / 1.) THF, hexane, from -78 deg C to -70 deg C, 15 min

3: NaBH₄ / CH₂Cl₂; acetic acid / 1 h / 0 - 5 °C

4: p-toluenesulfonic acid / 1.) reflux, 3 h, 2.) room temperature, overnight

5: 98 percent / 2 M NaOH / methanol / 0 - 5 °C

6: 92 percent / triethylamine (TEA), 4-(dimethylamino)pyridine (DMAP), isopropenyl chlorocarbonate (IPCC) / CH₂Cl₂ / 0.25 h / -5 °C

7: 100 percent / H₂ / 10percent Pd/C / propan-2-ol / 760 Torr

8: 97 percent / triethylamine (TEA) / tetrahydrofuran / 2 h / 0 - 5 °C

9: lithium diisopropylamide / 1.) THF, hexane, from -78 deg C to -70 deg C, 15 min

10: triethylamine (TEA), CuI / CH₂Cl₂ / 0.5 h / Ambient temperature

11: morpholine / tetrakis(triphenylphosphine)palladium / tetrahydrofuran / 0.17 h

12: 0.5 h

13: 54 percent / (1H-1,2,3-benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), NaHCO₃ / dimethylformamide / 24 h / Ambient temperature

14: 100 percent / H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature

With morpholine; dmap; sodium hydroxide; sodium tetrahydroborate; copper(l) iodide; Isopropenyl chloroformate; hydrogen; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; toluene-4-sulfonic acid; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jo00264a022

Reference yield:

: 117710-29-9,117773-54-3
C₄₉H₇₁N₅O₁₄*C₂HF₃O₂

: 117733-99-0
(5S,10S,14S,15R,18S,22S,24aS)-18-Amino-14-hydroxy-5-isobutyl-10,15-diisopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / (1H-1,2,3-benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), NaHCO₃ / dimethylformamide / 24 h / Ambient temperature

2: 100 percent / H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature

With hydrogen; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00264a022