C₁₄H₁₃N₃O

Base Information

• Chemical Name: C₁₄H₁₃N₃O
• CAS No.: 1393598-36-1
• Molecular Formula: C₁₄H₁₃N₃O
• Molecular Weight: 239.277
• Mol file: 1393598-36-1.mol

Synonyms:C₁₄H₁₃N₃O

Chemical Property of C₁₄H₁₃N₃O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₃N₃O

There total 4 articles about C₁₄H₁₃N₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

C7H6BrClN2O (1393598-49-6) + o-toluidine (95-53-4) → C14H13N3O (1393598-36-1)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 85 - 95 ℃; Inert atmosphere;

DOI:10.1021/co300078f

Reference yield:

tert-butyl (2-bromopyridin-3-yl)(methyl)carbamate (1393598-48-5) → C14H13N3O (1393598-36-1)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 25 °C

2: triethylamine / toluene / 0 - 25 °C

3: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 85 - 95 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; toluene;

DOI:10.1021/co300078f

Reference yield:

N-(2-bromopyridin-3-yl)-N-methylamine (872492-60-9) → C14H13N3O (1393598-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / toluene / 0 - 25 °C

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 85 - 95 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; toluene;

DOI:10.1021/co300078f

upstream raw materials:

(2-bromo-pyridin-3-yl)-carbamic acid tert-butyl ester

tert-butyl (2-bromopyridin-3-yl)(methyl)carbamate

N-(2-bromopyridin-3-yl)-N-methylamine

C₇H₆BrClN₂O