(7aS)-7a-[(4-bromophenyl)methyl]-2-(3,5-dichlorophenyl)dihydro-1H-pyrrolo[1,2-c]imidazole-1,3,6(2H,5H)-trione

Base Information

• Chemical Name: (7aS)-7a-[(4-bromophenyl)methyl]-2-(3,5-dichlorophenyl)dihydro-1H-pyrrolo[1,2-c]imidazole-1,3,6(2H,5H)-trione
• CAS No.: 852456-54-3
• Molecular Formula: C₁₉H₁₃BrCl₂N₂O₃
• Molecular Weight: 468.134

Synonyms:(7aS)-7a-[(4-bromophenyl)methyl]-2-(3,5-dichlorophenyl)dihydro-1H-pyrrolo[1,2-c]imidazole-1,3,6(2H,5H)-trione

Chemical Property of (7aS)-7a-[(4-bromophenyl)methyl]-2-(3,5-dichlorophenyl)dihydro-1H-pyrrolo[1,2-c]imidazole-1,3,6(2H,5H)-trione

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Technology Process of (7aS)-7a-[(4-bromophenyl)methyl]-2-(3,5-dichlorophenyl)dihydro-1H-pyrrolo[1,2-c]imidazole-1,3,6(2H,5H)-trione

There total 1 articles about (7aS)-7a-[(4-bromophenyl)methyl]-2-(3,5-dichlorophenyl)dihydro-1H-pyrrolo[1,2-c]imidazole-1,3,6(2H,5H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6R,7aS)-7a-(4-bromobenzyl)-2-(3,5-dichlorophenyl)-6-hydroxytetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione (336812-15-8) → (7aS)-7a-[(4-bromophenyl)methyl]-2-(3,5-dichlorophenyl)dihydro-1H-pyrrolo[1,2-c]imidazole-1,3,6(2H,5H)-trione (852456-54-3)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

(7aS)-7a-[(4-bromophenyl)methyl]-2-(3,5-dichlorophenyl)dihydro-1H-pyrrolo[1,2-c]imidazole-1,3,6(2H,5H)-trione (852456-54-3) + D-cysteine ethyl ester hydrochloride (75521-14-1) → C24H22BrCl2N3O4S

Guidance literature:

With triethylamine; toluene-4-sulfonic acid; In toluene; for 7h; Heating / reflux; azeotropic removal of water;

Reference yield:

(7aS)-7a-[(4-bromophenyl)methyl]-2-(3,5-dichlorophenyl)dihydro-1H-pyrrolo[1,2-c]imidazole-1,3,6(2H,5H)-trione (852456-54-3) + (S)-(-)-lactamide (2043-43-8) → (2S,5S,7a'S)-7a'-[(4-bromophenyl)-methyl]-2'-(3,5-dichlorophenyl)-5-methyldihydro-1'H,4H-spiro[1,3-oxazolidine-2,6'-pyrrolo[1,2-c]imidazole]-1',3',4(2'H)-trione + (2R,5S,7a'S)-7a'-[(4-bromophenyl)-methyl]-2'-(3,5-dichlorophenyl)-5-methyldihydro-1'H,4H-spiro[1,3-oxazolidine-2,6'-pyrrolo[1,2-c]imidazole]-1',3',4(2'H)-trione

Guidance literature:

toluene-4-sulfonic acid; In xylene; for 18h; Heating / reflux; azeotropic removal of water;

upstream raw materials:

(6R,7aS)-7a-(4-bromobenzyl)-2-(3,5-dichlorophenyl)-6-hydroxytetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione

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