Technology Process of (2S,6R)-2-(4-methoxyphenethyl)-6-(4-methoxyphenyl)tetrahydro-2H-pyran
There total 9 articles about (2S,6R)-2-(4-methoxyphenethyl)-6-(4-methoxyphenyl)tetrahydro-2H-pyran which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(4-methoxyphenyl)-2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethanone;
With
sodium tetrahydroborate;
In
tetrahydrofuran; diethyl ether;
at 0 - 20 ℃;
for 1h;
With
triethylsilane; trifluoroacetic acid;
In
tetrahydrofuran; diethyl ether;
at 0 - 20 ℃;
for 1h;
DOI:10.1002/ejoc.201300097
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium tetrahydroborate / methanol / 1 h
2.1: toluene-4-sulfonic acid; methanol / 15 h / Inert atmosphere
3.1: carbon tetrabromide; triphenylphosphine; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
4.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
4.2: 2 h / 20 °C
5.1: copper(ll) sulfate pentahydrate; water / methanol / 1.5 h / 60 °C
6.1: sodium tetrahydroborate / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C
6.2: 1 h / 0 - 20 °C
With
methanol; sodium tetrahydroborate; copper(ll) sulfate pentahydrate; carbon tetrabromide; water; sodium hydride; toluene-4-sulfonic acid; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201300097
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
1.2: 2 h / 20 °C
2.1: copper(ll) sulfate pentahydrate; water / methanol / 1.5 h / 60 °C
3.1: sodium tetrahydroborate / methanol / 1 h
4.1: toluene-4-sulfonic acid; methanol / 15 h / Inert atmosphere
5.1: carbon tetrabromide; triphenylphosphine; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
6.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
6.2: 2 h / 20 °C
7.1: copper(ll) sulfate pentahydrate; water / methanol / 1.5 h / 60 °C
8.1: sodium tetrahydroborate / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C
8.2: 1 h / 0 - 20 °C
With
methanol; sodium tetrahydroborate; copper(ll) sulfate pentahydrate; carbon tetrabromide; water; sodium hydride; toluene-4-sulfonic acid; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201300097
