4-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-benzene-1,2-diamine

Base Information

Chemical Name:4-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-benzene-1,2-diamine
CAS No.:1026426-43-6
Molecular Formula:C₂₁H₂₉N₃O
Molecular Weight:339.481
Hs Code.:

Synonyms:4-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-benzene-1,2-diamine

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Chemical Property of 4-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-benzene-1,2-diamine

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Technology Process of 4-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-benzene-1,2-diamine

There total 8 articles about 4-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-benzene-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-2-nitro-phenylamine

: 1026426-43-6
4-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-benzene-1,2-diamine

Guidance literature:: With hydrogen; palladium catalyst; In ethanol;
DOI:10.1021/jm960723m

Reference yield:

: 1197-55-3
4-aminophenylacetic acid

: 1026426-43-6
4-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-benzene-1,2-diamine

Guidance literature:: Multi-step reaction with 7 steps

1: H₂SO₄

2: pyridine

3: 15 g / 70percent HNO₃, Ac₂O / -10 °C

4: 5N aq. HCl

5: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole / tetrahydrofuran / 18 h / Ambient temperature

6: BH₃*THF / tetrahydrofuran / 5 h / Heating

7: H₂ / palladium catalyst / ethanol

With pyridine; hydrogenchloride; borane-THF; sulfuric acid; hydrogen; nitric acid; acetic anhydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium catalyst; In tetrahydrofuran; ethanol;
DOI:10.1021/jm960723m

Reference yield:

: 116435-82-6
2-(4-amino-3-nitrophenyl)acetic acid

: 1026426-43-6
4-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-benzene-1,2-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole / tetrahydrofuran / 18 h / Ambient temperature

2: BH₃*THF / tetrahydrofuran / 5 h / Heating

3: H₂ / palladium catalyst / ethanol

With borane-THF; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium catalyst; In tetrahydrofuran; ethanol;
DOI:10.1021/jm960723m