C₄₁H₅₂N₂O₅SSi

Base Information

• Chemical Name: C₄₁H₅₂N₂O₅SSi
• CAS No.: 447408-43-7
• Molecular Formula: C₄₁H₅₂N₂O₅SSi
• Molecular Weight: 713.026
• Mol file: 447408-43-7.mol

Synonyms:C₄₁H₅₂N₂O₅SSi

Chemical Property of C₄₁H₅₂N₂O₅SSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₅₂N₂O₅SSi

There total 6 articles about C₄₁H₅₂N₂O₅SSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2S,6R,7S,8R,12S)-2-[3-(9-Bora-bicyclo[3.3.1]non-9-yl)-propyl]-6-(tert-butyl-diphenyl-silanyloxy)-12-hydroxy-10-((Z)-5-iodo-pent-4-enyl)-4-(toluene-4-sulfonyl)-4,10-diaza-tricyclo[6.2.2.02,7]dodecan-3-one → C41H52N2O5SSi (447408-43-7)

Guidance literature:

(1S,2S,6R,7S,8R,12S)-2-[3-(9-Bora-bicyclo[3.3.1]non-9-yl)-propyl]-6-(tert-butyl-diphenyl-silanyloxy)-12-hydroxy-10-((Z)-5-iodo-pent-4-enyl)-4-(toluene-4-sulfonyl)-4,10-diaza-tricyclo[6.2.2.0^2,7]dodecan-3-one; With water; In ethyl acetate;

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Ti₂CO₃; triphenyl-arsane; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/1521-3773(20020503)41:9<1581::AID-ANIE1581>3.0.CO;2-F

Reference yield:

(Z)-5-Iodo-pent-4-enylamine (447408-39-1) → C41H52N2O5SSi (447408-43-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 65 percent / weakly acidic aluminum oxide / dimethylsulfoxide / 120 h / 20 °C

2.1: 100 percent / NaBH₄ / methanol / 0 °C

3.1: tetrahydrofuran / 20 °C

4.1: H₂O / ethyl acetate

4.2: Pd(dppf)Cl₂; Tl₂CO₃; AsPh₃ / tetrahydrofuran; dimethylformamide

With aluminum oxide; sodium tetrahydroborate; water; In tetrahydrofuran; methanol; dimethyl sulfoxide; ethyl acetate; 1.1: Michael addition / 4.2: Suzuki reaction;

DOI:10.1002/1521-3773(20020503)41:9<1581::AID-ANIE1581>3.0.CO;2-F

Reference yield:

((Z)-5-Iodo-pent-4-enyl)-carbamic acid benzyl ester (447408-48-2) → C41H52N2O5SSi (447408-43-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 35 percent / trimethylsilyl iodide / acetonitrile / 0 °C

2.1: 65 percent / weakly acidic aluminum oxide / dimethylsulfoxide / 120 h / 20 °C

3.1: 100 percent / NaBH₄ / methanol / 0 °C

4.1: tetrahydrofuran / 20 °C

5.1: H₂O / ethyl acetate

5.2: Pd(dppf)Cl₂; Tl₂CO₃; AsPh₃ / tetrahydrofuran; dimethylformamide

With aluminum oxide; sodium tetrahydroborate; trimethylsilyl iodide; water; In tetrahydrofuran; methanol; dimethyl sulfoxide; ethyl acetate; acetonitrile; 2.1: Michael addition / 5.2: Suzuki reaction;

DOI:10.1002/1521-3773(20020503)41:9<1581::AID-ANIE1581>3.0.CO;2-F

upstream raw materials:

(Z)-5-Iodo-pent-4-enylamine

((Z)-5-Iodo-pent-4-enyl)-carbamic acid benzyl ester

8a-allyl-4-(tert-butyl-diphenyl-silanyloxy)-5-methylene-2-(toluene-4-sulfonyl)-3,4,4a,8a-tetrahydro-2H,5H-isoquinoline-1,6-dione

(1S,2S,6R,7S,8R)-2-Allyl-6-(tert-butyl-diphenyl-silanyloxy)-10-((Z)-5-iodo-pent-4-enyl)-4-(toluene-4-sulfonyl)-4,10-diaza-tricyclo[6.2.2.0^2,7]dodecane-3,12-dione