dibenzyl 2-((R)-4-amino-5-(benzyloxy)-5-oxopentanamido)-6-((tert-butoxycarbonyl)amino)heptanedioate

Base Information

Chemical Name:dibenzyl 2-((R)-4-amino-5-(benzyloxy)-5-oxopentanamido)-6-((tert-butoxycarbonyl)amino)heptanedioate
CAS No.:1269619-55-7
Molecular Formula:C₃₈H₄₇N₃O₉
Molecular Weight:689.806
Hs Code.:

Synonyms:dibenzyl 2-((R)-4-amino-5-(benzyloxy)-5-oxopentanamido)-6-((tert-butoxycarbonyl)amino)heptanedioate

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Chemical Property of dibenzyl 2-((R)-4-amino-5-(benzyloxy)-5-oxopentanamido)-6-((tert-butoxycarbonyl)amino)heptanedioate

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Technology Process of dibenzyl 2-((R)-4-amino-5-(benzyloxy)-5-oxopentanamido)-6-((tert-butoxycarbonyl)amino)heptanedioate

There total 13 articles about dibenzyl 2-((R)-4-amino-5-(benzyloxy)-5-oxopentanamido)-6-((tert-butoxycarbonyl)amino)heptanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1269619-52-4
(5R)-tribenzyl 1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

: 1269619-55-7
dibenzyl 2-((R)-4-amino-5-(benzyloxy)-5-oxopentanamido)-6-((tert-butoxycarbonyl)amino)heptanedioate

Guidance literature:: With piperidine; In dichloromethane;
DOI:10.1021/jm101535e

Reference yield:

: 1269619-42-2
(R)-1-benzyl 5-tert-butyl 2-((tert-butoxycarbonyl)amino)pentanedioate

: 1269619-55-7
dibenzyl 2-((R)-4-amino-5-(benzyloxy)-5-oxopentanamido)-6-((tert-butoxycarbonyl)amino)heptanedioate

Guidance literature:: Multi-step reaction with 5 steps

1: 1 h

2: sodium carbonate / 1,4-dioxane; water / 10 - 20 °C

3: 1,4-dioxane; water / 16 h / 20 °C

4: polystyrene bound carbodiimide; polystyrene bound DMAP / dichloromethane / 4 h / 20 °C

5: piperidine / dichloromethane

With piperidine; sodium carbonate; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jm101535e

Reference yield:

: 1227363-56-5
dibenzyl 2,6-bis((tert-butoxycarbonyl)amino)heptanedioate

: 1269619-55-7
dibenzyl 2-((R)-4-amino-5-(benzyloxy)-5-oxopentanamido)-6-((tert-butoxycarbonyl)amino)heptanedioate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / 1,4-dioxane / 2 h

2: triethylamine / methanol / 0.5 h / pH 7

3: polystyrene bound carbodiimide; polystyrene bound DMAP / dichloromethane / 4 h / 20 °C

4: piperidine / dichloromethane

With piperidine; hydrogenchloride; triethylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm101535e