4′-((5-cholesteryloxy-5-oxopentyl)oxy)biphenyl-4-yl 4-(dodecyloxy)benzoate

Base Information

• Chemical Name: 4′-((5-cholesteryloxy-5-oxopentyl)oxy)biphenyl-4-yl 4-(dodecyloxy)benzoate
• CAS No.: 1616352-81-8
• Molecular Formula: C₆₃H₉₀O₆
• Molecular Weight: 943.404
• Mol file: 1616352-81-8.mol

Synonyms:4′-((5-cholesteryloxy-5-oxopentyl)oxy)biphenyl-4-yl 4-(dodecyloxy)benzoate

Chemical Property of 4′-((5-cholesteryloxy-5-oxopentyl)oxy)biphenyl-4-yl 4-(dodecyloxy)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4′-((5-cholesteryloxy-5-oxopentyl)oxy)biphenyl-4-yl 4-(dodecyloxy)benzoate

There total 3 articles about 4′-((5-cholesteryloxy-5-oxopentyl)oxy)biphenyl-4-yl 4-(dodecyloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

p-dodecyloxybenzoic acid (2312-15-4) + cholesteryl 5-(4'-hydroxybiphenyl-4-yloxy)pentanoate (303173-71-9) → 4′-((5-cholesteryloxy-5-oxopentyl)oxy)biphenyl-4-yl 4-(dodecyloxy)benzoate (1616352-81-8)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 40 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tet.2014.05.072

Reference yield:

cholest-5-en-3-β-yl 5-bromopentanoate (86689-84-1) → 4′-((5-cholesteryloxy-5-oxopentyl)oxy)biphenyl-4-yl 4-(dodecyloxy)benzoate (1616352-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 85 °C / Inert atmosphere

2: dicyclohexyl-carbodiimide; dmap / dichloromethane / 24 h / 40 °C / Inert atmosphere

With dmap; potassium carbonate; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; 1: |Williamson Ether Synthesis;

DOI:10.1016/j.tet.2014.05.072

Reference yield:

4,4'-Dihydroxybiphenyl (92-88-6) → 4′-((5-cholesteryloxy-5-oxopentyl)oxy)biphenyl-4-yl 4-(dodecyloxy)benzoate (1616352-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 85 °C / Inert atmosphere

2: dicyclohexyl-carbodiimide; dmap / dichloromethane / 24 h / 40 °C / Inert atmosphere

With dmap; potassium carbonate; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; 1: |Williamson Ether Synthesis;

DOI:10.1016/j.tet.2014.05.072

upstream raw materials:

4,4'-Dihydroxybiphenyl

cholest-5-en-3-β-yl 5-bromopentanoate

p-dodecyloxybenzoic acid

cholesteryl 5-(4'-hydroxybiphenyl-4-yloxy)pentanoate