di-t-butyl 4-ethyl-3-(4-nitrobutyl)-5-oxo-2-tosyl-1H-pyrrole-1,2(2H,5H)-dicarboxylate

Base Information

Chemical Name:di-t-butyl 4-ethyl-3-(4-nitrobutyl)-5-oxo-2-tosyl-1H-pyrrole-1,2(2H,5H)-dicarboxylate
CAS No.:879130-15-1
Molecular Formula:C₂₇H₃₈N₂O₉S
Molecular Weight:566.673
Hs Code.:

Synonyms:di-t-butyl 4-ethyl-3-(4-nitrobutyl)-5-oxo-2-tosyl-1H-pyrrole-1,2(2H,5H)-dicarboxylate

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Chemical Property of di-t-butyl 4-ethyl-3-(4-nitrobutyl)-5-oxo-2-tosyl-1H-pyrrole-1,2(2H,5H)-dicarboxylate

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Technology Process of di-t-butyl 4-ethyl-3-(4-nitrobutyl)-5-oxo-2-tosyl-1H-pyrrole-1,2(2H,5H)-dicarboxylate

There total 12 articles about di-t-butyl 4-ethyl-3-(4-nitrobutyl)-5-oxo-2-tosyl-1H-pyrrole-1,2(2H,5H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: di-t-butyl 4-ethyl-3-(4-iodobutyl)-5-oxo-2-tosyl-1H-pyrrole-1,2(2H,5H)-dicarboxylate

: 879130-15-1
di-t-butyl 4-ethyl-3-(4-nitrobutyl)-5-oxo-2-tosyl-1H-pyrrole-1,2(2H,5H)-dicarboxylate

Guidance literature:: With 3,5-dihydroxyphenol; sodium nitrite; In N,N-dimethyl-formamide; at 20 ℃; for 7h;
DOI:10.1246/cl.2005.800

Reference yield:

: di-t-butyl 3-(4-acetoxybutyl)-4-ethyl-5-oxo-2-tosyl-1H-pyrrole-1,2(2H,5H)-dicarboxylate

: 879130-15-1
di-t-butyl 4-ethyl-3-(4-nitrobutyl)-5-oxo-2-tosyl-1H-pyrrole-1,2(2H,5H)-dicarboxylate

: 1263431-78-2
di-t-butyl 4-ethyl-3-(4-nitrobutyl)-5-oxo-4-tosyl-1H-pyrrole-1,2(4H,5H)-dicarboxylate

Guidance literature:: di-t-butyl 3-(4-acetoxybutyl)-4-ethyl-5-oxo-2-tosyl-1H-pyrrole-1,2(2H,5H)-dicarboxylate; With hydrogenchloride; methanol; at 20 ℃;

With sodium hydrogencarbonate; In methanol; water;

With 3,5-dihydroxyphenol; sodium nitrite; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1246/bcsj.20100168

Reference yield:

: 6-nitro-octane-1,5-diol

: 879130-15-1
di-t-butyl 4-ethyl-3-(4-nitrobutyl)-5-oxo-2-tosyl-1H-pyrrole-1,2(2H,5H)-dicarboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: 4-(dimethylamino)pyridine / tetrahydrofuran / 1 h / 0 - 20 °C

2: 67 percent / DBU / tetrahydrofuran / 0 - 20 °C

3: N-iodosuccinimide / acetone / 1 h / 20 °C

4: toluene / 48 h / 20 °C

5: tetrahydrofuran / 1.5 h / Heating

6: DMAP / acetonitrile / 1 h / -40 - 20 °C

7: aq. HCl / methanol / 20 °C

8: iodine; Ph₃P; imidazole / acetonitrile / 1 h / 20 °C

9: sodium nitrite; phloroglucinol dihydrate / dimethylformamide / 7 h / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; N-iodo-succinimide; 3,5-dihydroxyphenol; iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; sodium nitrite; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; 2: Barton's method;
DOI:10.1246/cl.2005.800