2,2-dioxo-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

Base Information

Chemical Name:2,2-dioxo-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis
CAS No.:107124-32-3
Molecular Formula:C₂₂H₂₇Cl₂N₃O₆S
Molecular Weight:532.445
Hs Code.:

2,2-dioxo-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis <N-(2-propyl)carbamate>

Synonyms:2,2-dioxo-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

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Chemical Property of 2,2-dioxo-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

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Technology Process of 2,2-dioxo-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

There total 5 articles about 2,2-dioxo-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 107124-31-2
2,2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole

: 1795-48-8
Isopropyl isocyanate

: 107124-32-3
2,2-dioxo-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

Guidance literature:: With dibutyltin diacetate; In dichloromethane; for 20h; Ambient temperature;

Reference yield:

: 107124-27-6
dimethyl 2,2-dioxo-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole-6,7-dicarboxylate

: 107124-32-3
2,2-dioxo-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

Guidance literature:: Multi-step reaction with 2 steps

1: AlH₃-ether / tetrahydrofuran / 1 h / -12 °C

2: 77 percent / dibutyltin diacetate / CH₂Cl₂ / 20 h / Ambient temperature

With dibutyltin diacetate; aluminium hydride * diethyl ether; In tetrahydrofuran; dichloromethane;

Reference yield:

: 3024-72-4
3,4-dichlorobenzoyl chloride

: 107124-32-3
2,2-dioxo-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / aq. 15percent NaOH / H₂O; diethyl ether / 16 h / 25 °C

2: 68 percent / acetic anhydride / 6 h / 120 °C

3: 76 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 18 h / Ambient temperature

4: AlBH₃ / tetrahydrofuran / 5 h / 35 °C

5: dibutyltin acetate / CHCl₃ / 12 h / 25 °C

With sodium hydroxide; dibutyltin diacetate; acetic anhydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; water;
DOI:10.1021/jm00394a030