(S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid {[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-methyl}-amide; hydriodide

Base Information

Chemical Name:(S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid {[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-methyl}-amide; hydriodide
CAS No.:109947-86-6
Molecular Formula:C₂₉H₃₈N₆O₅S*HI
Molecular Weight:710.636
Hs Code.:

(S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid {[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-methyl}-amide; hydriodide

Synonyms:(S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid {[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-methyl}-amide; hydriodide

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Chemical Property of (S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid {[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-methyl}-amide; hydriodide

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Technology Process of (S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid {[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-methyl}-amide; hydriodide

There total 7 articles about (S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid {[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-methyl}-amide; hydriodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 109947-83-3
4-[3-Oxo-3-piperidin-1-yl-2-(2-{[(S)-1-(toluene-4-sulfonyl)-pyrrolidine-2-carbonyl]-amino}-acetylamino)-propyl]-thiobenzimidic acid methyl ester; hydriodide

: 109947-86-6
(S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid {[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-methyl}-amide; hydriodide

Guidance literature:: With ammonium acetate; In methanol; at 60 ℃; for 3h;

Reference yield:

: 54731-09-8,118776-39-9
N-tosyl-L-prolyl chloride

: 109947-86-6
(S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid {[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-methyl}-amide; hydriodide

Guidance literature:: Multi-step reaction with 6 steps

1: NaOH / diethyl ether / 3 h

2: 1) 4-nitrophenole, DCC, 2) TEA / 1) pyridine, 24 h, RT, 2) 3 h

3: 1) 4-ethylmorpholine, isobutyl chlorocarbonate / 1) ethyl acetate, 15 min, 0 deg C, 2) 3 h

4: 60 percent / TEA, H₂S / pyridine / Ambient temperature

5: 50 percent / acetone / 0.25 h / Heating

6: 40 percent / CH₃COONH₄ / methanol / 3 h / 60 °C

With N-ethylmorpholine;; sodium hydroxide; 4-nitro-phenol; TEA; hydrogen sulfide; ammonium acetate; dicyclohexyl-carbodiimide; isobutyl chloroformate; In pyridine; methanol; diethyl ether; acetone;

Reference yield:

: 109947-74-2
Tosyl-L-prolylglycin

: 109947-86-6
(S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid {[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-methyl}-amide; hydriodide

Guidance literature:: Multi-step reaction with 5 steps

1: 1) 4-nitrophenole, DCC, 2) TEA / 1) pyridine, 24 h, RT, 2) 3 h

2: 1) 4-ethylmorpholine, isobutyl chlorocarbonate / 1) ethyl acetate, 15 min, 0 deg C, 2) 3 h

3: 60 percent / TEA, H₂S / pyridine / Ambient temperature

4: 50 percent / acetone / 0.25 h / Heating

5: 40 percent / CH₃COONH₄ / methanol / 3 h / 60 °C

With N-ethylmorpholine;; 4-nitro-phenol; TEA; hydrogen sulfide; ammonium acetate; dicyclohexyl-carbodiimide; isobutyl chloroformate; In pyridine; methanol; acetone;