5-(3-{1-[4-amino-3-(1,2-dihydroxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl}-5-chloro-2-ethoxy-6-methylphenyl)-N,N-dimethylpyridine-2-carboxamide

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Chemical Name:5-(3-{1-[4-amino-3-(1,2-dihydroxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl}-5-chloro-2-ethoxy-6-methylphenyl)-N,N-dimethylpyridine-2-carboxamide
CAS No.:1426699-57-1
Molecular Formula:C₂₆H₃₀ClN₇O₄
Molecular Weight:540.022
Hs Code.:

5-(3-{1-[4-amino-3-(1,2-dihydroxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl}-5-chloro-2-ethoxy-6-methylphenyl)-N,N-dimethylpyridine-2-carboxamide

Synonyms:5-(3-{1-[4-amino-3-(1,2-dihydroxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl}-5-chloro-2-ethoxy-6-methylphenyl)-N,N-dimethylpyridine-2-carboxamide

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Chemical Property of 5-(3-{1-[4-amino-3-(1,2-dihydroxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl}-5-chloro-2-ethoxy-6-methylphenyl)-N,N-dimethylpyridine-2-carboxamide

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Technology Process of 5-(3-{1-[4-amino-3-(1,2-dihydroxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl}-5-chloro-2-ethoxy-6-methylphenyl)-N,N-dimethylpyridine-2-carboxamide

There total 8 articles about 5-(3-{1-[4-amino-3-(1,2-dihydroxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl}-5-chloro-2-ethoxy-6-methylphenyl)-N,N-dimethylpyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1426699-56-0
5-{3-[1-(4-amino-3-vinyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-methylphenyl}-N,N-dimethylpyridine-2-carboxamide

: 1426699-57-1
5-(3-{1-[4-amino-3-(1,2-dihydroxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl}-5-chloro-2-ethoxy-6-methylphenyl)-N,N-dimethylpyridine-2-carboxamide

Guidance literature:: With osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; In tert-butyl alcohol; at 20 ℃;

Reference yield:

: 1382996-91-9
1-(5-chloro-2-ethoxy-3-iodo-4-methylphenyl)ethan-1-one

: 1426699-57-1
5-(3-{1-[4-amino-3-(1,2-dihydroxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl}-5-chloro-2-ethoxy-6-methylphenyl)-N,N-dimethylpyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 95 °C / Inert atmosphere

2: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

3: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / dichloromethane / 20 °C

4: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h / 140 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide; water / 100 °C / Inert atmosphere

6: osmium(VIII) oxide; 4-methylmorpholine N-oxide; water / tert-butyl alcohol / 20 °C

With methanol; sodium tetrahydroborate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3,5-trichloro-2,4,6-triazine; water; sodium carbonate; potassium carbonate; caesium carbonate; 4-methylmorpholine N-oxide; N,N-dimethyl-formamide; potassium iodide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1426699-16-2
5-(3-acetyl-5-chloro-2-ethoxy-6-methylphenyl)-N,N-dimethylpyridine-2-carboxamide

: 1426699-57-1
5-(3-{1-[4-amino-3-(1,2-dihydroxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl}-5-chloro-2-ethoxy-6-methylphenyl)-N,N-dimethylpyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

2: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / dichloromethane / 20 °C

3: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h / 140 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide; water / 100 °C / Inert atmosphere

5: osmium(VIII) oxide; 4-methylmorpholine N-oxide; water / tert-butyl alcohol / 20 °C

With methanol; sodium tetrahydroborate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3,5-trichloro-2,4,6-triazine; water; sodium carbonate; caesium carbonate; 4-methylmorpholine N-oxide; N,N-dimethyl-formamide; potassium iodide; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;