N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-3-[2-(3,5-difluorophenyl)acetamido]propanamide

Base Information

Chemical Name:N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-3-[2-(3,5-difluorophenyl)acetamido]propanamide
CAS No.:1356955-72-0
Molecular Formula:C₃₂H₂₉F₂N₅O₂S
Molecular Weight:585.677
Hs Code.:

Synonyms:N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-3-[2-(3,5-difluorophenyl)acetamido]propanamide

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Chemical Property of N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-3-[2-(3,5-difluorophenyl)acetamido]propanamide

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Technology Process of N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-3-[2-(3,5-difluorophenyl)acetamido]propanamide

There total 6 articles about N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-3-[2-(3,5-difluorophenyl)acetamido]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1072918-46-7
2-(p-aminophenyl)-7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine

: 1356955-67-3
3-[2-(3,5-difluorophenyl)acetamido]propanoic acid

: 1356955-72-0
N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-3-[2-(3,5-difluorophenyl)acetamido]propanamide

Guidance literature:: 3-[2-(3,5-difluorophenyl)acetamido]propanoic acid; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

2-(p-aminophenyl)-7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.10.051

Reference yield:

: 1207741-56-7
7-benzyl-2-(p-nitrophenyl)-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine

: 1356955-72-0
N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-3-[2-(3,5-difluorophenyl)acetamido]propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; tin(ll) chloride / methanol; water / 0.5 h / Reflux

1.2: pH 9

2.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

With hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In methanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2011.10.051

Reference yield:

: 1370417-14-3
3-[2-(3,5-difluorophenyl)acetamido]propanoic acid methyl ester

: 1356955-72-0
N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-3-[2-(3,5-difluorophenyl)acetamido]propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol / 1 h / 20 °C

1.2: pH 2

2.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.10.051