3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide

Base Information

Chemical Name:3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide
CAS No.:1465825-70-0
Molecular Formula:C₂₈H₃₀ClN₅O₅S
Molecular Weight:584.096
Hs Code.:

Synonyms:3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide

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Technology Process of 3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide

There total 5 articles about 3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52085-97-9
3-(2-chlorophenyl)propionyl chloride

: C₁₉H₂₃N₅O₄S

: 1465825-70-0
3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2014.01.039

Reference yield:

: 925702-74-5
C₁₀H₁₀FN₃O₅

: 1465825-70-0
3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: ammonium formate; palladium 10% on activated carbon / tetrahydrofuran; ethanol

3: acetic acid / tetrahydrofuran; ethanol; 1,4-dioxane / 20 °C

4: triethylamine / dichloromethane / 20 °C

With palladium 10% on activated carbon; ammonium formate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.01.039

Reference yield:

: 1465826-19-0
C₁₄H₂₀N₄O₆

: 1465825-70-0
3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium formate; palladium 10% on activated carbon / tetrahydrofuran; ethanol

2: acetic acid / tetrahydrofuran; ethanol; 1,4-dioxane / 20 °C

3: triethylamine / dichloromethane / 20 °C

With palladium 10% on activated carbon; ammonium formate; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.01.039