(S)-2-(8-((4-fluorophenoxy)carbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid

Base Information

• Chemical Name: (S)-2-(8-((4-fluorophenoxy)carbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid
• CAS No.: 1025716-65-7
• Molecular Formula: C₂₄H₂₁FN₂O₇S
• Molecular Weight: 500.504
• Mol file: 1025716-65-7.mol

Synonyms:(S)-2-(8-((4-fluorophenoxy)carbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid

Chemical Property of (S)-2-(8-((4-fluorophenoxy)carbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(8-((4-fluorophenoxy)carbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid

There total 6 articles about (S)-2-(8-((4-fluorophenoxy)carbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ (S)-2-(8-((4-fluorophenoxy)carbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (1025716-65-7)

Guidance literature:

Reference yield: 69.0%

(S)-tert-butyl ((8-(((4-fluorophenoxy)carbonyl)amino)dibenzo[b,d]furan-3-yl)sulfonyl)-L-valinate → (S)-2-(8-((4-fluorophenoxy)carbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (1025716-65-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2017.11.027

Reference yield:

8-nitrodibenzo[b,d]furan-3-sulfonyl chloride (1025718-83-5) → (S)-2-(8-((4-fluorophenoxy)carbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (1025716-65-7)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 86 h / 20 °C

3: dmap / dichloromethane / 24 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2017.11.027

upstream raw materials:

3-aminodibenzofuran

8-nitrodibenzo[b,d]furan-3-sulfonyl chloride

(S)-3-methyl-2-(8-nitro-dibenzofuran-3-sulfonylamino)-butyric acid tert-butyl ester

(S)-2-(8-amino-dibenzofuran-3-sulfonylamino)-3-methyl-butyric acid tert-butyl ester