2-Amino-1-(2,5-dimethylphenyl)ethanol

Base Information

• Chemical Name: 2-Amino-1-(2,5-dimethylphenyl)ethanol
• CAS No.: 133562-38-6
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.235
• DSSTox Substance ID: DTXSID801262956
• Nikkaji Number: J532.137I
• Mol file: 133562-38-6.mol

Synonyms:133562-38-6;2-amino-1-(2,5-dimethylphenyl)ethan-1-ol;2-AMINO-1-(2,5-DIMETHYLPHENYL)ETHANOL;2-Amino-1-[2,5-dimethylphenyl]ethanol;DTXSID801262956;AKOS000123206;EN300-1147089;I+/--(Aminomethyl)-2,5-dimethylbenzenemethanol

Chemical Property of 2-Amino-1-(2,5-dimethylphenyl)ethanol

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 165.115364102
• Heavy Atom Count: 12
• Complexity: 138

Purity/Quality:

2-AMINO-1-(2,5-DIMETHYLPHENYL)ETHAN-1-OL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)C)C(CN)O

Technology Process of 2-Amino-1-(2,5-dimethylphenyl)ethanol

There total 3 articles about 2-Amino-1-(2,5-dimethylphenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-[2-(2,5-dimethyl-phenyl)-2-hydroxy-ethyl]-isoindole-1,3-dione (1415315-65-9) → 2-amino-1-(2,5-dimethyl-phenyl)ethanol (133562-38-6)

Guidance literature:

With hydrazine hydrate; In water; at 60 ℃; for 3h;

DOI:10.1080/00397911.2011.603876

Reference yield:

2-[2-(2,5-dimethyl-phenyl)-2-oxo-ethyl]-isoindole-1,3-dione (313495-39-5) → 2-amino-1-(2,5-dimethyl-phenyl)ethanol (133562-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium cyanoborohydride; acetic acid / 24 h / 20 °C

2: hydrazine hydrate / water / 3 h / 60 °C

With sodium cyanoborohydride; hydrazine hydrate; acetic acid; In water;

DOI:10.1080/00397911.2011.603876

Reference yield:

2-bromo-1-(2,5-dimethylphenyl)ethan-1-one (75840-13-0) → 2-amino-1-(2,5-dimethyl-phenyl)ethanol (133562-38-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.25 h / 20 °C / Ionic liquid

2: sodium cyanoborohydride; acetic acid / 24 h / 20 °C

3: hydrazine hydrate / water / 3 h / 60 °C

With sodium cyanoborohydride; hydrazine hydrate; acetic acid; In water;

DOI:10.1080/00397911.2011.603876

upstream raw materials:

2-bromo-1-(2,5-dimethylphenyl)ethan-1-one

2-[2-(2,5-dimethyl-phenyl)-2-hydroxy-ethyl]-isoindole-1,3-dione

2-[2-(2,5-dimethyl-phenyl)-2-oxo-ethyl]-isoindole-1,3-dione