9-butyryl-2-(4-chlorophenyl)-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one

Base Information

Chemical Name:9-butyryl-2-(4-chlorophenyl)-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one
CAS No.:135301-47-2
Molecular Formula:C₂₀H₁₉ClN₂OS₂
Molecular Weight:402.969
Hs Code.:

Synonyms:9-butyryl-2-(4-chlorophenyl)-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one

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Chemical Property of 9-butyryl-2-(4-chlorophenyl)-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one

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Technology Process of 9-butyryl-2-(4-chlorophenyl)-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one

There total 9 articles about 9-butyryl-2-(4-chlorophenyl)-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 173549-10-5
9-butyryl-2-(4-chlorophenyl)-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one

: 135301-47-2
9-butyryl-2-(4-chlorophenyl)-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one

Guidance literature:: With triethylsilane; In trifluoroacetic acid; for 15h; Ambient temperature;
DOI:10.1016/0223-5234(96)88305-X

Reference yield:

: 135279-10-6
4-oxo-4,5,6,7-tetrahydrothieno<2,3-b>thiepin-5-acetonitrile

: 135301-47-2
9-butyryl-2-(4-chlorophenyl)-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / conc. HCl, acetic acid / 4 h / Heating

2: sodium acetate / ethanol / 15 h / Heating

3: sodium acetate / acetic acid / 3 h / Heating

4: 82 percent / HBr / dimethylsulfoxide; acetic acid / 0.5 h / Ambient temperature

5: 1.) AlCl₃ / 1.) CH₂Cl₂, from 0 deg C to 10 deg C, 0.5 h, 2.) CH₂Cl₂, reflux, 1 h

6: 62 percent / triethylsilane / trifluoroacetic acid / 15 h / Ambient temperature

With hydrogenchloride; triethylsilane; aluminium trichloride; hydrogen bromide; sodium acetate; acetic acid; In ethanol; acetic acid; dimethyl sulfoxide; trifluoroacetic acid;
DOI:10.1016/0223-5234(96)88305-X

Reference yield:

: 135278-97-6
4-oxo-4,5,6,7-tetrahydrothieno<2,3-b>thiepin-5-acetic acid

: 135301-47-2
9-butyryl-2-(4-chlorophenyl)-5,6-dihydrothieno<2',3':2,3>thiepino<4,5-c>pyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium acetate / ethanol / 15 h / Heating

2: sodium acetate / acetic acid / 3 h / Heating

3: 82 percent / HBr / dimethylsulfoxide; acetic acid / 0.5 h / Ambient temperature

4: 1.) AlCl₃ / 1.) CH₂Cl₂, from 0 deg C to 10 deg C, 0.5 h, 2.) CH₂Cl₂, reflux, 1 h

5: 62 percent / triethylsilane / trifluoroacetic acid / 15 h / Ambient temperature

With triethylsilane; aluminium trichloride; hydrogen bromide; sodium acetate; In ethanol; acetic acid; dimethyl sulfoxide; trifluoroacetic acid;
DOI:10.1016/0223-5234(96)88305-X