Diisopropyl-phosphoramidous acid (1S,2R)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-methyl-propyl ester 2-cyano-ethyl ester

Base Information

Chemical Name:Diisopropyl-phosphoramidous acid (1S,2R)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-methyl-propyl ester 2-cyano-ethyl ester
CAS No.:195512-87-9
Molecular Formula:C₄₇H₅₄N₇O₇P
Molecular Weight:859.962
Hs Code.:

Diisopropyl-phosphoramidous acid (1S,2R)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-methyl-propyl ester 2-cyano-ethyl ester

Synonyms:Diisopropyl-phosphoramidous acid (1S,2R)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-methyl-propyl ester 2-cyano-ethyl ester

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Chemical Property of Diisopropyl-phosphoramidous acid (1S,2R)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-methyl-propyl ester 2-cyano-ethyl ester

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Technology Process of Diisopropyl-phosphoramidous acid (1S,2R)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-methyl-propyl ester 2-cyano-ethyl ester

There total 10 articles about Diisopropyl-phosphoramidous acid (1S,2R)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-methyl-propyl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 195512-83-5
N-(9-{(1R,2S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-hydroxy-propoxymethyl}-9H-purin-6-yl)-benzamide

: 195512-87-9
Diisopropyl-phosphoramidous acid (1S,2R)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-methyl-propyl ester 2-cyano-ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 0.5h; Ambient temperature;
DOI:10.1002/hlca.19970800513

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 195512-87-9
Diisopropyl-phosphoramidous acid (1S,2R)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-methyl-propyl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / (Bu₄N)ClO₄ / pyridine / 1 h / Ambient temperature

2: 84 percent / (i-Pr)2EtN / tetrahydrofuran / 0.5 h / Ambient temperature

With tetrabutylammonium perchlorate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine;
DOI:10.1002/hlca.19970800513

Reference yield:

: 123558-45-2
2R-chloromethoxy-1,3S-dibenzyloxybutane

: 195512-87-9
Diisopropyl-phosphoramidous acid (1S,2R)-2-(6-benzoylamino-purin-9-ylmethoxy)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-methyl-propyl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 50 percent / Et₃N / dimethylformamide / 18 h / Ambient temperature

2: 93 percent / NH₃ / methanol / 17 h / 110 °C

3: 70 percent / Pd(OH)2 / ethanol / 17 h / 80 °C

4: pyridine / 0.5 h / Ambient temperature

5: pyridine / 1.5 h / Ambient temperature

6: NH₃, H₂O / 1.5 h / 0 °C

7: 91 percent / (Bu₄N)ClO₄ / pyridine / 1 h / Ambient temperature

8: 84 percent / (i-Pr)2EtN / tetrahydrofuran / 0.5 h / Ambient temperature

With pyridine; palladium dihydroxide; tetrabutylammonium perchlorate; ammonia; water; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800513