(2S,5S)-5-(2-Benzyloxycarbonylamino-ethyl)-piperidine-2-carboxylic acid ethyl ester

Base Information

Chemical Name:(2S,5S)-5-(2-Benzyloxycarbonylamino-ethyl)-piperidine-2-carboxylic acid ethyl ester
CAS No.:176588-20-8
Molecular Formula:C₁₈H₂₆N₂O₄
Molecular Weight:334.415
Hs Code.:

Synonyms:(2S,5S)-5-(2-Benzyloxycarbonylamino-ethyl)-piperidine-2-carboxylic acid ethyl ester

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Chemical Property of (2S,5S)-5-(2-Benzyloxycarbonylamino-ethyl)-piperidine-2-carboxylic acid ethyl ester

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Technology Process of (2S,5S)-5-(2-Benzyloxycarbonylamino-ethyl)-piperidine-2-carboxylic acid ethyl ester

There total 7 articles about (2S,5S)-5-(2-Benzyloxycarbonylamino-ethyl)-piperidine-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 176588-19-5
(2S,5S)-5-(2-Benzyloxycarbonylamino-ethyl)-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

: 176588-20-8
(2S,5S)-5-(2-Benzyloxycarbonylamino-ethyl)-piperidine-2-carboxylic acid ethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/0040-4039(96)00140-2

Reference yield:

: 149733-38-0
(S)-6-oxo-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

: 176588-20-8
(2S,5S)-5-(2-Benzyloxycarbonylamino-ethyl)-piperidine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LiHMDS / 1.) THF, -78 deg C

2: LiEt₃BH / tetrahydrofuran

3: Et₃SiH, BF₃*OEt₂ / CH₂Cl₂

4: 89 percent / H₂ / PtO₂ / ethanol; CHCl₃

5: 85 percent / Et₃N / CH₂Cl₂

6: 86 percent / TFA / CH₂Cl₂

With triethylsilane; boron trifluoride diethyl etherate; hydrogen; lithium triethylborohydride; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; chloroform;
DOI:10.1016/0040-4039(96)00140-2

Reference yield:

: 128726-44-3
(S)-6-oxo-piperidine-2-carboxylic acid ethyl ester

: 176588-20-8
(2S,5S)-5-(2-Benzyloxycarbonylamino-ethyl)-piperidine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / DMAP / CH₂Cl₂

2: 1.) LiHMDS / 1.) THF, -78 deg C

3: LiEt₃BH / tetrahydrofuran

4: Et₃SiH, BF₃*OEt₂ / CH₂Cl₂

5: 89 percent / H₂ / PtO₂ / ethanol; CHCl₃

6: 85 percent / Et₃N / CH₂Cl₂

7: 86 percent / TFA / CH₂Cl₂

With triethylsilane; dmap; boron trifluoride diethyl etherate; hydrogen; lithium triethylborohydride; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; chloroform;
DOI:10.1016/0040-4039(96)00140-2