2-Bromo-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 2-Bromo-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester
• CAS No.: 1250999-20-2
• Molecular Formula: C₁₁H₁₆BrN₃O₂
• Molecular Weight: 302.171
• Mol file: 1250999-20-2.mol

Synonyms:2-bromo-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

Chemical Property of 2-Bromo-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester

Chemical Property:

• Boiling Point: 432.4±35.0 °C(Predicted)
• PKA: 4.62±0.20(Predicted)
• Density: 1.52±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

tert-butyl2-bromo-6,8-dihydro-5H-imidazo[1,2-a]pyrazine-7-carboxylate ^*data from reagent suppliers

Safty Information:

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Technology Process of 2-Bromo-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester

There total 7 articles about 2-Bromo-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

di-tert-butyl dicarbonate (24424-99-5) + C6H8BrN3 → 2-bromo-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (1250999-20-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield: 15.0%

2,3-dibromo-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (1613148-22-3) → 2-bromo-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (1250999-20-2)

Guidance literature:

With isopropylmagnesium chloride; In tetrahydrofuran; at -25 ℃; for 0.466667h; Inert atmosphere;

Reference yield:

C6H4BrN3 → 2-bromo-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (1250999-20-2)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium borohydride; ethanol / 12 h / 0 - 50 °C

2: triethylamine / dichloromethane / 0 - 20 °C

With lithium borohydride; ethanol; triethylamine; In dichloromethane;

upstream raw materials:

2,3-dibromo-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

di-tert-butyl dicarbonate

ethyl imidazo[1,2-a]pyrazine-2-carboxylate

imidazo <1,2-a>pyrazine-2-carboxylic acid

Downstream raw materials:

(R)-N,N-bis(tert-butoxycarbonyl)-5-(7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-yl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

3-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-2-yl)pyridin-2-amine

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