(+/-)-2-acetyl-7-(N-4-chlorophenylaminosulfonyl)-3-(1-piperidinocarbonyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(+/-)-2-acetyl-7-(N-4-chlorophenylaminosulfonyl)-3-(1-piperidinocarbonyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:833457-77-5
Molecular Formula:C₂₃H₂₆ClN₃O₄S
Molecular Weight:475.996
Hs Code.:

Synonyms:(+/-)-2-acetyl-7-(N-4-chlorophenylaminosulfonyl)-3-(1-piperidinocarbonyl)-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (+/-)-2-acetyl-7-(N-4-chlorophenylaminosulfonyl)-3-(1-piperidinocarbonyl)-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (+/-)-2-acetyl-7-(N-4-chlorophenylaminosulfonyl)-3-(1-piperidinocarbonyl)-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about (+/-)-2-acetyl-7-(N-4-chlorophenylaminosulfonyl)-3-(1-piperidinocarbonyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 106-47-8
4-chloro-aniline

: 833457-72-0
(+/-)-2-acetyl-3-(1-piperidinocarbonyl)-7-sulfonyl chloride-1,2,3,4-tetrahydroisoquinoline

: 833457-77-5
(+/-)-2-acetyl-7-(N-4-chlorophenylaminosulfonyl)-3-(1-piperidinocarbonyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With pyridine; sodium hydrogencarbonate; In ethyl acetate; for 12h;
DOI:10.1021/jm049368n

Reference yield:

: 110-89-4
piperidine

: 833457-77-5
(+/-)-2-acetyl-7-(N-4-chlorophenylaminosulfonyl)-3-(1-piperidinocarbonyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / 1-hydroxybenzotriazole; N-methylmorpholine; [benzotriazol-1-yloxytris(dimethylamino)phosphonium]*PF₆ / CH₂Cl₂ / 20 °C

2: 44 percent / chlorosulfonic acid / 20 °C

3: 58 percent / NaHCO₃; pyridine / ethyl acetate / 12 h

With 4-methyl-morpholine; pyridine; chlorosulfonic acid; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In dichloromethane; ethyl acetate;
DOI:10.1021/jm049368n

Reference yield:

: 143767-54-8
(R,S)-2-acetyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

: 833457-77-5
(+/-)-2-acetyl-7-(N-4-chlorophenylaminosulfonyl)-3-(1-piperidinocarbonyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / 1-hydroxybenzotriazole; N-methylmorpholine; [benzotriazol-1-yloxytris(dimethylamino)phosphonium]*PF₆ / CH₂Cl₂ / 20 °C

2: 44 percent / chlorosulfonic acid / 20 °C

3: 58 percent / NaHCO₃; pyridine / ethyl acetate / 12 h

With 4-methyl-morpholine; pyridine; chlorosulfonic acid; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In dichloromethane; ethyl acetate;
DOI:10.1021/jm049368n