methyl (2S)-2-amino-3-[4-(1,1-dioxido-3-oxoisothiazolidin-5-yl)-3-methylphenyl]propanoate

Base Information

Chemical Name:methyl (2S)-2-amino-3-[4-(1,1-dioxido-3-oxoisothiazolidin-5-yl)-3-methylphenyl]propanoate
CAS No.:850321-21-0
Molecular Formula:C₁₄H₁₈N₂O₅S
Molecular Weight:326.373
Hs Code.:

Synonyms:methyl (2S)-2-amino-3-[4-(1,1-dioxido-3-oxoisothiazolidin-5-yl)-3-methylphenyl]propanoate

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Chemical Property of methyl (2S)-2-amino-3-[4-(1,1-dioxido-3-oxoisothiazolidin-5-yl)-3-methylphenyl]propanoate

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Technology Process of methyl (2S)-2-amino-3-[4-(1,1-dioxido-3-oxoisothiazolidin-5-yl)-3-methylphenyl]propanoate

There total 9 articles about methyl (2S)-2-amino-3-[4-(1,1-dioxido-3-oxoisothiazolidin-5-yl)-3-methylphenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 850321-20-9
methyl (2S)-2-[(benzyloxy)carbonyl]amino-3-[4-(2-tert-butyl-1,1-dioxido-3-oxo-2,3-dihydroisothiazol-5-yl)-3-methylphenyl]propanoate

: 850321-21-0
methyl (2S)-2-amino-3-[4-(1,1-dioxido-3-oxoisothiazolidin-5-yl)-3-methylphenyl]propanoate

Guidance literature:: With trifluoroacetic acid; at 130 ℃; for 0.0833333h; mocrowave irradiation;
DOI:10.1021/jm0600904

Reference yield:

: 850321-16-3
methyl (2S)-2-[(benzyloxy)carbonyl]amino-3-(4-bromo-3-methylphenyl)propanoate

: 850321-21-0
methyl (2S)-2-amino-3-[4-(1,1-dioxido-3-oxoisothiazolidin-5-yl)-3-methylphenyl]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / triethylamine; palladium acetate; O-(dicyclohexylphosphino)biphenyl / dioxane / 0.5 h / 80 °C

2: 80 percent / sodium periodate; ammonium acetate / tetrahydrofuran / 24 h / 25 °C

3: 62 percent / potassium carbonate; [1,1'-bis(diphenylphosphino)ferrocene]PdCl₂*CH₂Cl₂ / dioxane / 24 h / 80 °C

4: 88 percent / L-selectride / tetrahydrofuran / 0.17 h / -78 °C

5: 74 percent / trifluoroacetic acid / 0.08 h / 130 °C / mocrowave irradiation

With ammonium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium periodate; O-(dicyclohexylphosphino)biphenyl; palladium diacetate; L-Selectride; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; 3: Suzuki coupling;
DOI:10.1021/jm0600904

Reference yield:

: 905281-17-6
methyl (2Z)-2-[(benzyloxy)carbonyl]amino-3-(4-bromo-3-methylphenyl)acrylate

: 850321-21-0
methyl (2S)-2-amino-3-[4-(1,1-dioxido-3-oxoisothiazolidin-5-yl)-3-methylphenyl]propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / (R,R)-1,2-[(o-MeOPh)(Ph)P]2CH₂CH₂(1,5-cyclooctadiene)Rh*BF₄; H₂ / ethanol / 24 h / 2585.74 Torr

2: 91 percent / triethylamine; palladium acetate; O-(dicyclohexylphosphino)biphenyl / dioxane / 0.5 h / 80 °C

3: 80 percent / sodium periodate; ammonium acetate / tetrahydrofuran / 24 h / 25 °C

4: 62 percent / potassium carbonate; [1,1'-bis(diphenylphosphino)ferrocene]PdCl₂*CH₂Cl₂ / dioxane / 24 h / 80 °C

5: 88 percent / L-selectride / tetrahydrofuran / 0.17 h / -78 °C

6: 74 percent / trifluoroacetic acid / 0.08 h / 130 °C / mocrowave irradiation

With ammonium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium periodate; (Z,Z)-cycloocta-1,5-diene(R,R-1,2-bis(2,5-diethylphospholanyl)benzene)rhodium(I) tetrafluoroborate; O-(dicyclohexylphosphino)biphenyl; hydrogen; palladium diacetate; L-Selectride; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; 4: Suzuki coupling;
DOI:10.1021/jm0600904