N,N',N-tris[(3-(benzyloxy)-1-methyl-2-oxo-1H-pyridin-4-yl)carbonyl]cyclotriseryl trilactone

Base Information

• Chemical Name: N,N',N-tris[(3-(benzyloxy)-1-methyl-2-oxo-1H-pyridin-4-yl)carbonyl]cyclotriseryl trilactone
• CAS No.: 197142-25-9
• Molecular Formula: C₅₁H₄₈N₆O₁₅
• Molecular Weight: 984.973
• Mol file: 197142-25-9.mol

Synonyms:N,N',N-tris[(3-(benzyloxy)-1-methyl-2-oxo-1H-pyridin-4-yl)carbonyl]cyclotriseryl trilactone

Chemical Property of N,N',N-tris[(3-(benzyloxy)-1-methyl-2-oxo-1H-pyridin-4-yl)carbonyl]cyclotriseryl trilactone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N',N-tris[(3-(benzyloxy)-1-methyl-2-oxo-1H-pyridin-4-yl)carbonyl]cyclotriseryl trilactone

There total 3 articles about N,N',N-tris[(3-(benzyloxy)-1-methyl-2-oxo-1H-pyridin-4-yl)carbonyl]cyclotriseryl trilactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

(3S,7S,11S)-3,7,11-triamino-1,5,9-trioxacyclodecane-2,6,10-trione trihydrochloride (104530-71-4) + 3-(benzyloxy)-1-methyl-2(1H)-4-carboxoylpyridinone chloride (197142-24-8) → N,N',N-tris[(3-(benzyloxy)-1-methyl-2-oxo-1H-pyridin-4-yl)carbonyl]cyclotriseryl trilactone (197142-25-9)

Guidance literature:

With triethylamine; In dichloromethane; for 1h;

DOI:10.1021/ja970718n

Reference yield:

tris(N-trityl-L-serine) trilactone (88109-07-3) → N,N',N-tris[(3-(benzyloxy)-1-methyl-2-oxo-1H-pyridin-4-yl)carbonyl]cyclotriseryl trilactone (197142-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / HCl / ethanol / 0.25 h / Heating

2: 3 percent / triethylamine / CH₂Cl₂ / 1 h

With hydrogenchloride; triethylamine; In ethanol; dichloromethane; 1: detritylation / 2: Acylation;

DOI:10.1021/ja970718n

Reference yield:

3-benzyloxy-4-carboxy-1-methyl-2(1H)-pyridinone (169237-38-1) → N,N',N-tris[(3-(benzyloxy)-1-methyl-2-oxo-1H-pyridin-4-yl)carbonyl]cyclotriseryl trilactone (197142-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / benzene / 1 h

2: 3 percent / triethylamine / CH₂Cl₂ / 1 h

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; benzene; 1: Chlorination / 2: Acylation;

DOI:10.1021/ja970718n

upstream raw materials:

(3S,7S,11S)-3,7,11-triamino-1,5,9-trioxacyclodecane-2,6,10-trione trihydrochloride

3-(benzyloxy)-1-methyl-2(1H)-4-carboxoylpyridinone chloride

tris(N-trityl-L-serine) trilactone

3-benzyloxy-4-carboxy-1-methyl-2(1H)-pyridinone