(5S,6S)-((2S,3R)-2-methyl-1-(tosyloxy)hex-5-en-3-yl)-6,8-dimethyl-5-(triethylsilyloxy)non-8-enoate

Base Information

Chemical Name:(5S,6S)-((2S,3R)-2-methyl-1-(tosyloxy)hex-5-en-3-yl)-6,8-dimethyl-5-(triethylsilyloxy)non-8-enoate
CAS No.:935457-52-6
Molecular Formula:C₃₁H₅₂O₆SSi
Molecular Weight:580.902
Hs Code.:

Synonyms:(5S,6S)-((2S,3R)-2-methyl-1-(tosyloxy)hex-5-en-3-yl)-6,8-dimethyl-5-(triethylsilyloxy)non-8-enoate

Suppliers and Price of (5S,6S)-((2S,3R)-2-methyl-1-(tosyloxy)hex-5-en-3-yl)-6,8-dimethyl-5-(triethylsilyloxy)non-8-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5S,6S)-((2S,3R)-2-methyl-1-(tosyloxy)hex-5-en-3-yl)-6,8-dimethyl-5-(triethylsilyloxy)non-8-enoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (5S,6S)-((2S,3R)-2-methyl-1-(tosyloxy)hex-5-en-3-yl)-6,8-dimethyl-5-(triethylsilyloxy)non-8-enoate

There total 18 articles about (5S,6S)-((2S,3R)-2-methyl-1-(tosyloxy)hex-5-en-3-yl)-6,8-dimethyl-5-(triethylsilyloxy)non-8-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 935457-54-8
(5S,6S)-6,8-dimethyl-5-(triethylsilyloxy)non-8-enoic acid

: 874914-31-5
(2S,3R)-3-hydroxy-2-methylhex-5-enyl 4-methylbenzenesulfonate

: 935457-52-6
(5S,6S)-((2S,3R)-2-methyl-1-(tosyloxy)hex-5-en-3-yl)-6,8-dimethyl-5-(triethylsilyloxy)non-8-enoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 1.5h;
DOI:10.1055/s-2007-967943

Reference yield:

: 935457-61-7
(5S,6S)-6,8-dimethyl-5-(triethylsilyloxy)non-8-en-1-ol

: 935457-52-6
(5S,6S)-((2S,3R)-2-methyl-1-(tosyloxy)hex-5-en-3-yl)-6,8-dimethyl-5-(triethylsilyloxy)non-8-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 - 20 °C

2: NaClO₂; 2-methyl-2-butene; NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 0.5 h / 20 °C

3: 82 percent / DCC; DMAP / CH₂Cl₂ / 1.5 h / 0 - 20 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; Dess-Martin periodane; dicyclohexyl-carbodiimide; In dichloromethane; water; tert-butyl alcohol; 1: Dess-Martin oxidation;
DOI:10.1055/s-2007-967943

Reference yield:

: C₁₇H₃₄O₂Si

: 935457-52-6
(5S,6S)-((2S,3R)-2-methyl-1-(tosyloxy)hex-5-en-3-yl)-6,8-dimethyl-5-(triethylsilyloxy)non-8-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: NaClO₂; 2-methyl-2-butene; NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 0.5 h / 20 °C

2: 82 percent / DCC; DMAP / CH₂Cl₂ / 1.5 h / 0 - 20 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; dicyclohexyl-carbodiimide; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1055/s-2007-967943