1-benzyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid (2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridin-3-ylmethyl)amide

Base Information

Chemical Name:1-benzyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid (2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridin-3-ylmethyl)amide
CAS No.:1418023-60-5
Molecular Formula:C₃₁H₂₃N₅O₄
Molecular Weight:529.555
Hs Code.:

Synonyms:1-benzyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid (2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridin-3-ylmethyl)amide

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Chemical Property of 1-benzyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid (2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridin-3-ylmethyl)amide

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Technology Process of 1-benzyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid (2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridin-3-ylmethyl)amide

There total 7 articles about 1-benzyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid (2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridin-3-ylmethyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418025-78-1
3-aminomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one trifluoroacetate

: 63987-74-6
1-benzyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid

: 1418023-60-5
1-benzyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid (2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridin-3-ylmethyl)amide

Guidance literature:: 1-benzyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid; With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 0.166667h; under 760.051 Torr; Inert atmosphere;

3-aminomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one trifluoroacetate; at 20 ℃; under 760.051 Torr; Inert atmosphere;

Reference yield:

: 131109-74-5
1-(2-chloro-pyridin-3-yl)propan-1-one

: 1418023-60-5
1-benzyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid (2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridin-3-ylmethyl)amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: (1S)-(+)-10-camphorsulfonic acid / 1,4-dioxane / 95 °C / 760.05 Torr / Inert atmosphere; Sealed tube

2.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 25 °C / 760.05 Torr / Inert atmosphere

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 90 °C / 760.05 Torr / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / 45 °C / 760.05 Torr / Inert atmosphere

5.1: dichloromethane / 4 h / 25 °C / 760.05 Torr / Inert atmosphere

6.1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 0.17 h / 20 °C / 760.05 Torr / Inert atmosphere

6.2: 20 °C / 760.05 Torr / Inert atmosphere

With dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); (1S)-(+)-10-camphorsulfonic acid; sodium hexamethyldisilazane; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1418025-75-8
3-bromomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one

: 1418023-60-5
1-benzyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid (2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridin-3-ylmethyl)amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / 45 °C / 760.05 Torr / Inert atmosphere

2.1: dichloromethane / 4 h / 25 °C / 760.05 Torr / Inert atmosphere

3.1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 0.17 h / 20 °C / 760.05 Torr / Inert atmosphere

3.2: 20 °C / 760.05 Torr / Inert atmosphere

With dmap; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;