2,4-Dichloro-5-trichloromethylpyrimidine

Base Information

• Chemical Name: 2,4-Dichloro-5-trichloromethylpyrimidine
• CAS No.: 153600-16-9
• Molecular Formula: C₅HCl₅N₂
• Molecular Weight: 266.341
• Mol file: 153600-16-9.mol

Synonyms:2,4-Dichloro-5-trichloromethylpyrimidine

Chemical Property of 2,4-Dichloro-5-trichloromethylpyrimidine

Chemical Property:

• Boiling Point: 334.8±37.0 °C(Predicted)
• PKA: -4.65±0.29(Predicted)
• Density: 1.762±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-Dichloro-5-trichloromethylpyrimidine

There total 3 articles about 2,4-Dichloro-5-trichloromethylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,6-dichloro-5-methylpyrimidine (1780-31-0) → 2,4-Dichloro-5-trichloromethylpyrimidine (153600-16-9)

Guidance literature:

With chlorine; for 35h; Heating; Irradiation;

DOI:10.1016/0022-1139(95)03386-6

Reference yield:

thymin (65-71-4,28806-14-6,691841-57-3) → 2,4-Dichloro-5-trichloromethylpyrimidine (153600-16-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / POCl₃, dimethylaniline / 1.) 25 deg C, 5 min, 2.) reflux, 20 h

2: 92 percent / Cl₂ / 35 h / Heating; Irradiation

With chlorine; 2,3-Dimethylaniline; trichlorophosphate;

DOI:10.1016/0022-1139(95)03386-6

Reference yield:

→ 2,4-Dichloro-5-trichloromethylpyrimidine (153600-16-9)

Guidance literature:

/BRN= 908893/, CH3CN;

upstream raw materials:

2,6-dichloro-5-methylpyrimidine

thymin

Downstream raw materials:

5-trifluoromethyluracil