3-{[(benzyloxy)carbonyl]amino}-1,1,1-trifluoropropan-2-yl trifluoromethanesulfonate

Base Information

• Chemical Name: 3-{[(benzyloxy)carbonyl]amino}-1,1,1-trifluoropropan-2-yl trifluoromethanesulfonate
• CAS No.: 1429913-36-9
• Molecular Formula: C₁₂H₁₁F₆NO₅S
• Molecular Weight: 395.279
• Mol file: 1429913-36-9.mol

Synonyms:3-{[(benzyloxy)carbonyl]amino}-1,1,1-trifluoropropan-2-yl trifluoromethanesulfonate

Chemical Property of 3-{[(benzyloxy)carbonyl]amino}-1,1,1-trifluoropropan-2-yl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{[(benzyloxy)carbonyl]amino}-1,1,1-trifluoropropan-2-yl trifluoromethanesulfonate

There total 2 articles about 3-{[(benzyloxy)carbonyl]amino}-1,1,1-trifluoropropan-2-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + benzyl (3,3,3-trifluoro-2-hydroxypropyl)carbamate (1429913-35-8) → 3-{[(benzyloxy)carbonyl]amino}-1,1,1-trifluoropropan-2-yl trifluoromethanesulfonate (1429913-36-9)

Guidance literature:

With triethylamine; In dichloromethane; at -40 ℃; for 1h;

Reference yield:

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) → 3-{[(benzyloxy)carbonyl]amino}-1,1,1-trifluoropropan-2-yl trifluoromethanesulfonate (1429913-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol / 5 h / 0 - 5 °C

1.2: 16 h / 70 °C

2.1: triethylamine / dichloromethane / 1 h / -40 °C

With sodium tetrahydroborate; triethylamine; In methanol; dichloromethane;

Reference yield:

3-{[(benzyloxy)carbonyl]amino}-1,1,1-trifluoropropan-2-yl trifluoromethanesulfonate (1429913-36-9) → benzyl (2-azido-3,3,3-trifluoropropyl)carbamate (1429913-37-0)

Guidance literature:

With sodium azide; In dimethyl sulfoxide; at 40 ℃; for 5h;

upstream raw materials:

N-(Benzyloxycarbonyloxy)succinimide

trifluoromethylsulfonic anhydride

benzyl (3,3,3-trifluoro-2-hydroxypropyl)carbamate

Downstream raw materials:

benzyl (2-azido-3,3,3-trifluoropropyl)carbamate

benzyl (2-amino-3,3,3-trifluoropropyl)carbamate

benzyl (2-amino-3,3,3-trifluoropropyl)carbamate oxalic acid

benzyl tert-butyl (3,3,3-trifluoropropane-1,2-diyl)biscarbamate