(E)-1-nitro-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene

Base Information

• Chemical Name: (E)-1-nitro-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene
• CAS No.: 1642593-91-6
• Molecular Formula: C₁₅H₁₀F₃NO₂
• Molecular Weight: 293.245
• Mol file: 1642593-91-6.mol

Synonyms:(E)-1-nitro-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene

Chemical Property of (E)-1-nitro-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene

Chemical Property:

Purity/Quality:

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Technology Process of (E)-1-nitro-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene

There total 2 articles about (E)-1-nitro-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-nitrophenyl)-1-phenylethylene (22057-84-7) + Umemoto's reagent → (E)-1-nitro-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene (1642593-91-6) + (Z)-1-nitro-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene

Guidance literature:

With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃; for 2h; Overall yield = 51 %; Overall yield = 39 mg; stereoselective reaction; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.3762/bjoc.10.108

Reference yield:

4-nitrobenzophenone (1144-74-7) → (E)-1-nitro-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene (1642593-91-6) + (Z)-1-nitro-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate / dimethyl sulfoxide / 2 h / 20 °C / Schlenk technique; Inert atmosphere; Irradiation

With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; sodium hexamethyldisilazane; In tetrahydrofuran; dimethyl sulfoxide; 1.1: |Wittig Olefination / 1.2: |Wittig Olefination;

DOI:10.3762/bjoc.10.108

upstream raw materials:

4-nitrobenzophenone

1-(4-nitrophenyl)-1-phenylethylene