R-(+)-5-(3'-hydroxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine

Base Information

• Chemical Name: R-(+)-5-(3'-hydroxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine
• CAS No.: 119835-84-6
• Molecular Formula: C₂₄H₂₃N₃O₇
• Molecular Weight: 465.463
• Mol file: 119835-84-6.mol

Synonyms:R-(+)-5-(3'-hydroxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine

Chemical Property of R-(+)-5-(3'-hydroxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of R-(+)-5-(3'-hydroxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine

There total 5 articles about R-(+)-5-(3'-hydroxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

R-(+)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-benzyloxyethoxy)methyl>-2-oxo-4-methoxypyrimidine (119835-83-5) → R-(+)-5-(3'-hydroxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine (119835-84-6)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; for 0.5h; under 2280 Torr;

DOI:10.1002/jhet.5570250561

Reference yield:

potassium phtalimide (1074-82-4) → R-(+)-5-(3'-hydroxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine (119835-84-6)

Guidance literature:

Multi-step reaction with 4 steps

1: dimethylformamide / 30 h / 120 °C

2: HCl (g) / CH₂Cl₂ / 3 h / 0 °C

3: 72 percent / K₂CO₃ (s) / CH₂Cl₂ / 48 h / Ambient temperature

4: 82 percent / H₂, 6 N HCl / 10percent Pd/C / methanol; CH₂Cl₂ / 0.5 h / 2280 Torr

With hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570250561

Reference yield:

R-(+)-1-benzyloxy-3-phtalimidopropanol (119835-79-9) → R-(+)-5-(3'-hydroxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine (119835-84-6)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl (g) / CH₂Cl₂ / 3 h / 0 °C

2: 72 percent / K₂CO₃ (s) / CH₂Cl₂ / 48 h / Ambient temperature

3: 82 percent / H₂, 6 N HCl / 10percent Pd/C / methanol; CH₂Cl₂ / 0.5 h / 2280 Torr

With hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1002/jhet.5570250561

upstream raw materials:

R-(+)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-benzyloxyethoxy)methyl>-2-oxo-4-methoxypyrimidine

potassium phtalimide

R-(+)-1-benzyloxy-3-phtalimidopropanol

2-((S)-3-Benzyloxy-2-chloromethoxy-propyl)-isoindole-1,3-dione

Downstream raw materials:

R-(+)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>uracil

R-(+)-5-(3'-benzyloxybenzyl)-1-<(1'-aminomethyl-2'-hydroxyethoxy)methyl>uracil