3-(3-Fluoro-4-morpholin-4-ylphenyl)-5-(oxan-2-yloxymethyl)-1,3-oxazolidin-2-one

Base Information

Chemical Name:3-(3-Fluoro-4-morpholin-4-ylphenyl)-5-(oxan-2-yloxymethyl)-1,3-oxazolidin-2-one
CAS No.:513068-92-3
Molecular Formula:C₁₉H₂₅FN₂O₅
Molecular Weight:380.416
Hs Code.:
DSSTox Substance ID:DTXSID301116435

Synonyms:513068-92-3;DTXSID301116435;FT-0715156;2-Oxazolidinone, 3-[3-fluoro-4-(4-morpholinyl)phenyl]-5-[[(tetrahydro-2H-pyran-2-yl)oxy]methyl]-

Suppliers and Price of 3-(3-Fluoro-4-morpholin-4-ylphenyl)-5-(oxan-2-yloxymethyl)-1,3-oxazolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(3-Fluoro-4-morpholin-4-ylphenyl)-5-(oxan-2-yloxymethyl)-1,3-oxazolidin-2-one

Chemical Property:

Melting Point:107-109 °C
Boiling Point:546.8±50.0 °C(Predicted)
Density:1.32±0.1 g/cm3(Predicted)
XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:380.17475006
Heavy Atom Count:27
Complexity:505

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCOC(C1)OCC2CN(C(=O)O2)C3=CC(=C(C=C3)N4CCOCC4)F

Technology Process of 3-(3-Fluoro-4-morpholin-4-ylphenyl)-5-(oxan-2-yloxymethyl)-1,3-oxazolidin-2-one

There total 3 articles about 3-(3-Fluoro-4-morpholin-4-ylphenyl)-5-(oxan-2-yloxymethyl)-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 513068-89-8
4-(4-bromo-2-fluorophenyl)morpholine

: 513068-35-4
5-tetrahydro-2H-2-pyranyloxymethyl-2-oxazolidinone

: 513068-92-3
3-{3-fluoro-4-morpholinophenyl}-5-(tetrahydro-2H-2-pyranyloxy-methyl)-2-oxazolidinone

Guidance literature:: With copper(l) iodide; (S,S)-1,2-diaminocyclohexane; potassium carbonate; In 1,4-dioxane; at 110 ℃; for 15h;
DOI:10.1021/ol026902h

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 513068-92-3
3-{3-fluoro-4-morpholinophenyl}-5-(tetrahydro-2H-2-pyranyloxy-methyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 12 h / 25 °C

2: 85 percent / copper(I) iodide; potassium carbonate; (+/-)-trans-1,2-diaminocyclohexane / dioxane / 15 h / 110 °C

With copper(l) iodide; (S,S)-1,2-diaminocyclohexane; pyridinium p-toluenesulfonate; potassium carbonate; In 1,4-dioxane; dichloromethane; 2: Goldberg coupling;
DOI:10.1021/ol026902h

Reference yield:

: 93246-53-8
3-fluoro-4-(morpholinyl)aniline

: 513068-92-3
3-{3-fluoro-4-morpholinophenyl}-5-(tetrahydro-2H-2-pyranyloxy-methyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: HNO₂

1.2: copper(I) bromide; HBr

2.1: 85 percent / copper(I) iodide; potassium carbonate; (+/-)-trans-1,2-diaminocyclohexane / dioxane / 15 h / 110 °C

With copper(l) iodide; (S,S)-1,2-diaminocyclohexane; cis-nitrous acid; potassium carbonate; In 1,4-dioxane; 1.2: Sandmeyer reaction / 2.1: Goldberg coupling;
DOI:10.1021/ol026902h