(S)-3-amino-2-({2-[(3'-hydroxy-biphenyl-2-ylmethyl)amino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride

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Chemical Name:(S)-3-amino-2-({2-[(3'-hydroxy-biphenyl-2-ylmethyl)amino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride
CAS No.:1400706-12-8
Molecular Formula:C₂₄H₂₇N₅O₄*ClH
Molecular Weight:485.97
Hs Code.:

Synonyms:(S)-3-amino-2-({2-[(3'-hydroxy-biphenyl-2-ylmethyl)amino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride

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Chemical Property of (S)-3-amino-2-({2-[(3'-hydroxy-biphenyl-2-ylmethyl)amino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride

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Technology Process of (S)-3-amino-2-({2-[(3'-hydroxy-biphenyl-2-ylmethyl)amino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride

There total 9 articles about (S)-3-amino-2-({2-[(3'-hydroxy-biphenyl-2-ylmethyl)amino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1415477-63-2
C₂₉H₃₅N₅O₆

: 1400706-12-8
(S)-3-amino-2-({2-[(3'-hydroxy-biphenyl-2-ylmethyl)amino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 3.5h;

Reference yield:

: 10365-98-7,1107579-37-2
3-methoxyphenylboronic acid

: 1400706-12-8
(S)-3-amino-2-({2-[(3'-hydroxy-biphenyl-2-ylmethyl)amino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.17 h / 150 °C / microwave irradiation

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: potassium acetate / ethanol / 1 h / 120 °C / microwave irradiation

4.1: boron tribromide / dichloromethane / 1 h / 0 °C

5.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 60 °C

5.2: pH 1

6.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

7.1: hydrogenchloride / 1,4-dioxane; methanol / 3.5 h / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; water; potassium acetate; boron tribromide; sodium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 162356-90-3
N-(tert-butoxycarbonyl)-2-bromobenzylamine

: 1400706-12-8
(S)-3-amino-2-({2-[(3'-hydroxy-biphenyl-2-ylmethyl)amino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.17 h / 150 °C / microwave irradiation

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: potassium acetate / ethanol / 1 h / 120 °C / microwave irradiation

4.1: boron tribromide / dichloromethane / 1 h / 0 °C

5.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 60 °C

5.2: pH 1

6.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

7.1: hydrogenchloride / 1,4-dioxane; methanol / 3.5 h / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; water; potassium acetate; boron tribromide; sodium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide;