1-(tert-butoxycarbonyl)-5-(4-cyanophenyl)-2-(5-cyanothien-2-yl)-1H-indole

Base Information

Chemical Name:1-(tert-butoxycarbonyl)-5-(4-cyanophenyl)-2-(5-cyanothien-2-yl)-1H-indole
CAS No.:1305348-84-8
Molecular Formula:C₂₅H₁₉N₃O₂S
Molecular Weight:425.511
Hs Code.:

Synonyms:1-(tert-butoxycarbonyl)-5-(4-cyanophenyl)-2-(5-cyanothien-2-yl)-1H-indole

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Chemical Property of 1-(tert-butoxycarbonyl)-5-(4-cyanophenyl)-2-(5-cyanothien-2-yl)-1H-indole

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Technology Process of 1-(tert-butoxycarbonyl)-5-(4-cyanophenyl)-2-(5-cyanothien-2-yl)-1H-indole

There total 3 articles about 1-(tert-butoxycarbonyl)-5-(4-cyanophenyl)-2-(5-cyanothien-2-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1305348-31-5
5-bromo-1-(tert-butoxycarbonyl)-2-(5-cyanothien-2-yl)-1H-indole

: 126747-14-6
4-cyanophenylboronic acid

: 1305348-84-8
1-(tert-butoxycarbonyl)-5-(4-cyanophenyl)-2-(5-cyanothien-2-yl)-1H-indole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; water; toluene; at 80 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.02.045

Reference yield:

: 1028752-18-2
C₁₆H₂₂BrNO₂Sn

: 1305348-84-8
1-(tert-butoxycarbonyl)-5-(4-cyanophenyl)-2-(5-cyanothien-2-yl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 24 h / 90 - 100 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / methanol; water; toluene / 24 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; methanol; water; toluene; 1: Stille coupling / 2: Suzuki coupling;
DOI:10.1016/j.bmc.2011.02.045

Reference yield:

: 2160-62-5
5-bromo-2-thiophenecarbonitrile

: 1305348-84-8
1-(tert-butoxycarbonyl)-5-(4-cyanophenyl)-2-(5-cyanothien-2-yl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 24 h / 90 - 100 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / methanol; water; toluene / 24 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; methanol; water; toluene; 1: Stille coupling / 2: Suzuki coupling;
DOI:10.1016/j.bmc.2011.02.045