(N_α-carbobenzyloxy-L-2-amino-6-acryloylamino)hexanoylglycine tert-butyl ester

Base Information

Chemical Name:(N_α-carbobenzyloxy-L-2-amino-6-acryloylamino)hexanoylglycine tert-butyl ester
CAS No.:366780-99-6
Molecular Formula:C₂₃H₃₃N₃O₆
Molecular Weight:447.532
Hs Code.:

(N<sub>α</sub>-carbobenzyloxy-L-2-amino-6-acryloylamino)hexanoylglycine tert-butyl ester

Synonyms:(N_α-carbobenzyloxy-L-2-amino-6-acryloylamino)hexanoylglycine tert-butyl ester

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Chemical Property of (N_α-carbobenzyloxy-L-2-amino-6-acryloylamino)hexanoylglycine tert-butyl ester

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Technology Process of (N_α-carbobenzyloxy-L-2-amino-6-acryloylamino)hexanoylglycine tert-butyl ester

There total 2 articles about (N_α-carbobenzyloxy-L-2-amino-6-acryloylamino)hexanoylglycine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 27532-96-3
glycine tert-butyl ester hydrochloride

: 366780-95-2
N_α-carbobenzyloxy-L-2-amino-6-acryloylaminohexanoic acid

: 366780-99-6
(N_α-carbobenzyloxy-L-2-amino-6-acryloylamino)hexanoylglycine tert-butyl ester

Guidance literature:: N_α-carbobenzyloxy-L-2-amino-6-acryloylaminohexanoic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; for 0.25h;

glycine tert-butyl ester hydrochloride; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/S0968-0896(01)00292-9

Reference yield:

: 2212-75-1
N₂-[(benzyloxy)carbonyl]-L-lysine

: 366780-99-6
(N_α-carbobenzyloxy-L-2-amino-6-acryloylamino)hexanoylglycine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / Et₃N / methanol / 12 h / 0 - 20 °C

2.1: EDC*HCl; Et₃N / CH₂Cl₂ / 0.25 h

2.2: 93 percent / CH₂Cl₂ / 12 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1016/S0968-0896(01)00292-9