methyl 4-benzoyl-5-(4-cyanophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-2-carboxylate

Base Information

Chemical Name:methyl 4-benzoyl-5-(4-cyanophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-2-carboxylate
CAS No.:1423137-12-5
Molecular Formula:C₂₆H₂₀N₂O₃
Molecular Weight:408.456
Hs Code.:

Synonyms:methyl 4-benzoyl-5-(4-cyanophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-2-carboxylate

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Chemical Property of methyl 4-benzoyl-5-(4-cyanophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-2-carboxylate

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Technology Process of methyl 4-benzoyl-5-(4-cyanophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-2-carboxylate

There total 2 articles about methyl 4-benzoyl-5-(4-cyanophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 82461-26-5
methyl N-p-cyanobenzylidenephenylglycinate

: 3623-15-2
phenyl propargyl ketone

: 1423137-12-5
methyl 4-benzoyl-5-(4-cyanophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-2-carboxylate

Guidance literature:: With (S,S_p)-R-Phosferrox; copper(II) acetate monohydrate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -40 ℃; for 48h; stereoselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1039/c5cy00422e

Reference yield:

: 3623-15-2
phenyl propargyl ketone

: 105-07-7
4-cyanobenzaldehyde

: 24461-61-8,26682-99-5,37760-98-8,6591-61-3
phenylglycine methyl ester

: 1423137-12-5
methyl 4-benzoyl-5-(4-cyanophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-2-carboxylate

: 1423137-13-6
methyl 4-benzoyl-5-(4-cyanophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-2-carboxylate

: methyl 4-benzoyl-5-(4-cyanophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-2-carboxylate

: methyl 4-benzoyl-5-(4-cyanophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-2-carboxylate

Guidance literature:: 4-cyanobenzaldehyde; phenylglycine methyl ester; With (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; In toluene; at 25 ℃; for 0.333333h; Molecular sieve;

phenyl propargyl ketone; In toluene; at 25 ℃; for 60h; Overall yield = 52 %; enantioselective reaction; Molecular sieve;
DOI:10.1039/c2ob26566d